| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | group | BEFREE | In addition, significant interaction effects between childhood abuse experiences and the COMT and MTHFR genetic variants on the development of male homosexuality were found. | 29289372 | 2018 | ||||
|
0.080 | GeneticVariation | group | BEFREE | This result suggests that COMT genotypes and cannabis use only influenced PE scores among individuals exposed to childhood abuse. | 23445265 | 2014 | ||||
|
0.080 | GeneticVariation | group | BEFREE | In addition, a significant interaction between COMT genotype and physical abuse was associated with better executive function in Val homozygotes, relative to those of the same genotype with no history of abuse. | 24252819 | 2014 | ||||
|
0.080 | GeneticVariation | group | BEFREE | The results of the present study suggest that anger-trait level is influenced by the interaction between childhood abuse and functional polymorphism in the COMT gene. | 20002200 | 2010 | ||||
|
0.080 | GeneticVariation | group | BEFREE | In COMT Val(158)Val carriers, but not in Val/Met and Met/Met carriers, childhood sexual abuse and the cumulative number of SLEs were associated with lower BDHI sum scores (P < 0.05). | 19906087 | 2010 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Further, the functional catechol-O-methyltransferase (COMT) Val158Met polymorphism interacted significantly with total CTQ abuse scores to impact perceived dissociation. | 17608961 | 2008 | ||||
|
0.080 | AlteredExpression | group | BEFREE | A common functional polymorphism that results in a three- to four-fold difference in catechol-O-methyltransferase (COMT) enzyme activity has been related to psychiatric disorders such as ultra-ultra rapid cycling bipolar disorder, drug abuse and alcoholism (Lachman et al., 1996a; Karayiorgou et al., 1997; Vandenbergh et al., 1997; Papolos et al., 1998; Tiihonen et al., 1999). | 11204347 | 2000 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Individuals with the high-activity COMT variant may have greater genetic vulnerability to drug abuse. | 9259381 | 1997 |