Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE The dystrophin-/-/utrophin-/-/ double knockout (dKO-Hom) mouse is a murine model of human Duchenne muscular dystrophy. 30689868 2019
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy. 30990876 2019
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE Utrophin is a fetal homologue of dystrophin that can subserve many dystrophin functions and is therefore under active investigation as a dystrophin replacement therapy for DMD. 30914715 2019
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 AlteredExpression disease BEFREE SSPN interacts with dystrophin, the DMD disease gene product, and its autosomal paralog utrophin, which is upregulated in DMD as a partial compensatory mechanism. 31039133 2019
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE These data illustrate the importance of monitoring utrophin and MyHC-emb levels in the preclinical evaluation of therapies and provide translational support for the use of developmental myosin as a disease biomarker in DMD clinical trials. 30304405 2019
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 AlteredExpression disease BEFREE Upregulation of utrophin, an autosomal and functional paralogue of dystrophin, is one of the most promising therapeutic strategies as it targets the primary cause of the disease and is applicable to all DMD patients regardless their genetic defects. 30964048 2019
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 AlteredExpression disease BEFREE sPIF promotes myoblast differentiation and utrophin expression while inhibiting fibrosis in Duchenne muscular dystrophy via the H19/miR-675/let-7 and miR-21 pathways. 30692507 2019
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE These results endorse the view that utrophin modulation has the potential to increase the quality life of all DMD patients whatever their mutation. 30417024 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 AlteredExpression disease BEFREE Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin-deficient mice and Duchenne muscular dystrophy. 29772070 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 AlteredExpression disease BEFREE Overall, these results highlight that activation of p38 in muscles can indeed lead to an attenuation of the dystrophic phenotype and reveal the potential role of celecoxib as a novel therapeutic agent for the treatment of DMD.-Péladeau, C., Adam, N. J., Jasmin, B. J. Celecoxib treatment improves muscle function in mdx mice and increases utrophin A expression. 29723037 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE We also measured urinary isoxanthopterin in wildtype mice and a number of dystrophic mouse models; the DMD mouse model (mdx), mdx mice overexpressing a variety of transgenic miniaturized and chimeric skeletal muscle-specific dystrophins and utrophin and the β-sarcoglycan deficient (Scgb<sup>-/-</sup>) mouse which represents type 2E human limb-girdle muscular dystrophy. 30312761 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE New mouse models, including utrophin haploinsufficient mdx (mdx/utrn+/-) mice, may better recapitulate DMD. 29879154 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE Up-regulation of the dystrophin-related gene utrophin represents a promising therapeutic strategy for the treatment of Duchenne Muscular Dystrophy (DMD). 29408646 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE In contrast, mice deficient for both dystrophin and utrophin (mdx/utrn<sup>-/-</sup>, or dKO) can be used to model severe DMD cardiomyopathy where pathophysiological indicators of heart failure are detectable by 8-10weeks of age. 28623080 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE Given that utrophin can compensate for dystrophin's absence and be regarded as a promising therapeutic target for Duchenne Muscular Dystrophy (DMD), we further detected the deep role of miR-150 in dystrophic muscle. 28108217 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE The mdx/utrn <sup>-/-</sup> mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of DMD. 28785010 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 GeneticVariation disease BEFREE A highly promising approach to therapy, applicable to all DMD patients irrespective to their genetic defect, is to modulate utrophin, a functional paralogue of dystrophin, able to compensate for the primary defects of DMD restoring sarcolemmal stability. 28252048 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE Dystrophin/utrophin double-knockout (dKO) mice develop a more severe and progressive muscular dystrophy than the mdx mice, the most common murine model of Duchenne muscular dystrophy (DMD). 29078808 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE A promising therapeutic approach deals with functional substitution of dystrophin by utrophin, a structural homolog that might be able to compensate dystrophin absence in DMD muscle fibers. 27988307 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE Increasing the levels of the dystrophin-related-protein utrophin is a highly promising therapy for DMD and has been shown to improve pathology in dystrophin-deficient mice. 29065908 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 AlteredExpression disease BEFREE Drug development for DMD has mainly used two strategies: (1) the restoration of dystrophin expression or the expression of the compensatory utrophin protein as an efficient surrogate, and (2) the mitigation of secondary downstream pathological mechanisms. 28486179 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 AlteredExpression disease BEFREE The functional improvement of dystrophic muscle achieved using let7-SBOs suggests a novel utrophin upregulation-based therapeutic strategy for DMD. 29045431 2017
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE We show that an adapted version of CRISPR/Cas9 increases the amount of utrophin, a known disease modifier in Duchenne muscular dystrophy (DMD). 26686765 2016
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE We show that sarcospan-mediated amelioration of muscular dystrophy in DMD mice is dependent on the presence of both utrophin and α7β1 integrin, even when they are individually expressed at therapeutic levels. 25504048 2015
Entrez Id: 7402
Gene Symbol: UTRN
UTRN
0.100 Biomarker disease BEFREE This detailed evaluation of the SMT C1100 drug series strongly endorses the therapeutic potential of utrophin modulation as a disease modifying therapeutic strategy for all DMD patients irrespective of their dystrophin mutation. 25935002 2015