Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression disease BEFREE IGF-I levels remain reduced in SGA children with short stature, as well as IGFBP-3 and acid-labile subunit levels. 31509834 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE The aim of this study was to investigate the relationship between IGF-1 standard deviation score (IGF-1 SDS) and LDL-C level in children and adolescents with short stature. 31122262 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression disease BEFREE GH and IGF-1 levels were low without short stature. 31152917 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Detection of GH and IGFBP-3 are important for the early diagnosis and comprehensive evaluation of children with dwarfism, and also in the detection of IGF-1 can reflect the therapeutic effect of dwarfism on recombinant human growth hormone (rhGH) treatment, which is worthy of application in clinics. 30988753 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 GeneticVariation disease BEFREE We describe the fourth patient with severe short stature presenting a novel homozygous IGF1 gene mutation. 31539878 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Since GH and IGF-I act on all these systems, we decided to study those parameters in a cohort of individuals with severe short stature due to untreated isolated GH deficiency (IGHD) caused by a mutation in the GHRH receptor gene. 30865930 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE However, other as yet unknown mechanisms not associated with the growth hormone (GH)-IGF-1 axis could be involved in growth retardation in idiopathic short stature. 31444966 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression disease BEFREE Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes. 30273774 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE While genetic causes of short stature were previously thought to primarily be associated with the GH-IGF-I axis, it is now established that multiple genetic anomalies not associated with the GH-IGF-I axis can result in short stature. 31555216 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE The detection of the GH-IGF-1 axis function can be carried out for the etiologic diagnosis of short stature. 31301056 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE In this context, and when studying the GH/IGF-I axis of subjects with two different syndromes that include severe short stature (SSS), we noticed different metabolic phenotypes in each cohort. 29306561 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Linear growth restriction is a unique feature of paediatric inflammatory bowel diseases (IBD), and reduced insulin-like growth factor (IGF-1) is a major determinant of short stature. 29893990 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression disease BEFREE The insulin-like growth factor1 receptor (IGF1R) is important in growth and development, and inactivating <i>IGF1R</i> mutations cause short stature and relatively high levels of serum IGF-I. 29789409 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Measurement of serum IGF-I and IGF-binding protein (IGFBP)-3 concentrations can complement assessment of GH status in the investigation of short stature and contribute to prediction of growth response during GH therapy. 29724795 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Letter to the Editor: History and clinical implications of PAPP-A2 in human growth: When reflecting on idiopathic short stature leads to a specific and new diagnosis: Understanding the concept of "low IGF-I availability". 29653372 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 GeneticVariation disease BEFREE A molecular diagnosis for short stature is important for affected individuals and their families and might inform treatment decisions surrounding use of growth hormone or insulin-like growth factor 1 therapy. 29397377 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Baseline Insulin like growth factor binding protein 3 (IGFBP - 3) along with ∆ IGF - 1 in the first 3 months of GH therapy level can be a marker of growth response to the rGH and/or rIGF - 1 therapy in children with non - growth hormone deficiency short stature. 30197657 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Although metabolic outcomes may be aided by dual therapy with GI and IGF-I, the one published study of the combination approach to treat children with non-GH-deficient short stature showed only a meager additional height response compared to that achieved with GH alone. 29493124 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 GeneticVariation disease BEFREE However, process dysfunctions in the GH⁻GHR⁻IGF-1 axis cause animal dwarfism. 29748515 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Association between Growth Hormone-Insulin-Like Growth Factor-1 Axis Gene Polymorphisms and Short Stature in Chinese Children. 29687007 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Nutritional Status in Short Stature Children Is Related to Both Ghrelin and Insulin-like Growth Factor I Concentrations. 27557428 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE We describe the case of a 3.8 years old girl with symmetrical short stature (-3.76 SDS), low IGF-1 and IGFBP-3, in presence of normal GH levels. 29025428 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Ames dwarf mice are deficient in GH, prolactin, and thyrotropin, whereas GHRKOs are GH resistant and are dwarf with decreased circulating IGF-1 and increased GH. 27688483 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE Fibroblasts of GH/IGF-1-deficient Snell dwarf mice also exhibited improved DNA repair capacity, showing that the persisting influence of peripubertal GH/IGF-1 status is not species-dependent. 28233247 2017
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker disease BEFREE We undertook a prospective study of 132 patients with short stature and suspected GH or IGF-1 insensitivity referred to our centre for genetic analysis. 28870985 2017