Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.200 Biomarker disease HPO
Entrez Id: 219736
Gene Symbol: STOX1
STOX1 		0.140 Biomarker disease HPO
Entrez Id: 10699
Gene Symbol: CORIN
CORIN 		0.120 Biomarker disease HPO
Entrez Id: 4000
Gene Symbol: LMNA
LMNA 		0.110 Biomarker disease HPO
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.100 Biomarker disease HPO
Entrez Id: 4179
Gene Symbol: CD46
CD46 		0.100 Biomarker disease HPO
Entrez Id: 3426
Gene Symbol: CFI
CFI 		0.100 Biomarker disease HPO
Entrez Id: 3075
Gene Symbol: CFH
CFH 		0.100 Biomarker disease HPO
Entrez Id: 101101692
Gene Symbol: HELLPAR
HELLPAR 		0.100 Biomarker disease HPO
Entrez Id: 4018
Gene Symbol: LPA
LPA 		0.020 GeneticVariation disease BEFREE <b>Objective:</b> The study tested whether cardiovascular corresponding LPA risk genotypes improve pre-eclampsia and coronary heart disease (CHD) risk prediction beyond conventional risk factors. 31113255 2019
Entrez Id: 283120
Gene Symbol: H19
H19 		0.010 GeneticVariation disease BEFREE (2) The loss of the H19 gene imprinting in the placental tissues of pre-eclampsia patients may be associated with severe hypertension, contributing to the pathogenic process of pre-eclampsia. 19342096 2009
Entrez Id: 6866
Gene Symbol: TAC3
TAC3 		0.040 AlteredExpression disease BEFREE - What is the cause of the elevated levels of neurokinin B during pre-eclampsia? 20074343 2010
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.100 GeneticVariation disease BEFREE Angiotensinogen gene M235T variant and pre-eclampsia in Romanian pregnant women. 12417054 2003
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.100 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. 14997002 2004
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.070 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia. 15905108 2005
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.200 Biomarker disease BEFREE Endothelial nitric oxide synthase gene influences the risk of pre-eclampsia, the recurrence of negative pregnancy events, and the maternal-fetal flow. 16915032 2006
Entrez Id: 4153
Gene Symbol: MBL2
MBL2 		0.030 GeneticVariation disease BEFREE Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction. 17314117 2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.040 Biomarker disease BEFREE Interleukin-1beta (IL-1beta), a pro-inflammatory cytokine, has been implicated in the genesis of pre-eclampsia. 18069648 2008
Entrez Id: 811
Gene Symbol: CALR
CALR 		0.020 AlteredExpression disease BEFREE Calreticulin mRNA and protein expression in placenta were not changed between pre-eclampsia and control pregnancies. 18417548 2008
Entrez Id: 2153
Gene Symbol: F5
F5 		0.050 Biomarker disease BEFREE Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis. 18752569 2008
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.100 GeneticVariation disease BEFREE Angiotensin II type 1 and 2 receptors gene polymorphisms in pre-eclampsia and normal pregnancy in three different populations. 19308748 2009
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.100 Biomarker disease BEFREE Angiotensin II is critical in pre-eclampsia pathogenesis. 21234519 2011
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.100 GeneticVariation disease BEFREE Angiotensinogen gene M235T and T174M polymorphisms and susceptibility of pre-eclampsia: a meta-analysis. 22881375 2012
Entrez Id: 4773
Gene Symbol: NFATC2
NFATC2 		0.010 AlteredExpression disease BEFREE NFAT-1, STAT-1 and AP-1 might be the central transcription factors in the pathogenesis of pre-eclampsia. 24931237 2014
Entrez Id: 406913
Gene Symbol: MIR126
MIR126 		0.010 AlteredExpression disease BEFREE miR-126 was downregulated in placentas from patients with pre-eclampsia and this correlated with decreased VEGF expression. 25341970 2014