Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10699
Gene Symbol: CORIN
CORIN 		0.120 GeneticVariation disease BEFREE CORIN variants and mutations impairing corin activation have been identified in people with hypertension and pre-eclampsia. 26259032 2015
Entrez Id: 3135
Gene Symbol: HLA-G
HLA-G 		0.090 Biomarker disease BEFREE HLA-G and CD8+ regulatory T cells in the inflammatory environment of pre-eclampsia. 27651521 2016
Entrez Id: 128
Gene Symbol: ADH5
ADH5 		0.010 Biomarker disease BEFREE GSNOR inhibitors offer a potentially promising option for the management of pre-eclampsia. 28271419 2017
Entrez Id: 387082
Gene Symbol: SUMO4
SUMO4 		0.010 Biomarker disease BEFREE SUMO-4 mRNA (qRT-PCR) and protein (Western blot and immunohistochemistry) were measured in Jar cells, BeWo cells, first trimester placental villous explants and placental tissues across normal gestation and in pre-eclampsia. 28545138 2017
Entrez Id: 3001
Gene Symbol: GZMA
GZMA 		0.010 Biomarker disease BEFREE GZMA) are predicted to play significant roles in the progress of EOPET, which will be confirmed by experiments in future. 28759171 2017
Entrez Id: 406986
Gene Symbol: MIR203A
MIR203A 		0.010 AlteredExpression disease BEFREE miR‑203 contributes to pre‑eclampsia via inhibition of VEGFA expression. 29436641 2018
Entrez Id: 2022
Gene Symbol: ENG
ENG 		0.020 Biomarker disease BEFREE Endoglin level, mean arterial blood pressure (MABP), and urinary protein/creatinine ratio were analyzed for correlation to investigate their relationship and the influence of endoglin on eclampsia severity. 29565476 2018
Entrez Id: 3646
Gene Symbol: EIF3E
EIF3E 		0.010 Biomarker disease BEFREE Int6 silencing alleviated the maternal clinical manifestations of pre-eclampsia and promoted placental angiogenesis in pregnant L-NAME-treated rats. 29895936 2018
Entrez Id: 26512
Gene Symbol: INTS6
INTS6 		0.010 Biomarker disease BEFREE Int6 silencing alleviated the maternal clinical manifestations of pre-eclampsia and promoted placental angiogenesis in pregnant L-NAME-treated rats. 29895936 2018
Entrez Id: 355
Gene Symbol: FAS
FAS 		0.030 GeneticVariation disease BEFREE FAS A-670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre-eclampsia and may contribute to HELLP syndrome: a case-controlled study. 30066360 2018
Entrez Id: 5228
Gene Symbol: PGF
PGF 		0.090 Biomarker disease BEFREE Placental growth factor testing for suspected pre-eclampsia is cost-saving and improves maternal outcomes. 31240854 2019
Entrez Id: 5228
Gene Symbol: PGF
PGF 		0.090 Biomarker disease BEFREE Placental growth factor (PlGF) is decreased in early gestation of pregnant women who subsequently develop pre-eclampsia. 31452230 2020
Entrez Id: 4018
Gene Symbol: LPA
LPA 		0.020 Biomarker disease BEFREE Lipoprotein(a) and apolipoprotein(a) phenotype do not contribute significantly to the pathogenesis of pre-eclampsia. 9292635 1997
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.100 GeneticVariation disease BEFREE Angiotensinogen gene variation in a population case-control study of preeclampsia/eclampsia in Australians and Chinese. 9378138 1997
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1 		0.030 AlteredExpression disease BEFREE Angiotensin II type 1 receptor gene expression in the fetus may contribute to the aetiology of pre-eclampsia. 9719367 1998
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.200 GeneticVariation disease BEFREE Glu298Asp polymorphism in the eNOS gene could be an individual's risk factor and may modulate progression to an eclampsia complication of preeclampsia in the Turkish population. 21793998 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE A meta-analysis of tumor necrosis factor-α and FAS/FASL polymorphisms with risk of pre-eclampsia. 30606056 2019
Entrez Id: 355
Gene Symbol: FAS
FAS 		0.030 GeneticVariation disease BEFREE A meta-analysis of tumor necrosis factor-α and FAS/FASL polymorphisms with risk of pre-eclampsia. 30606056 2019
Entrez Id: 356
Gene Symbol: FASLG
FASLG 		0.030 GeneticVariation disease BEFREE A meta-analysis of tumor necrosis factor-α and FAS/FASL polymorphisms with risk of pre-eclampsia. 30606056 2019
Entrez Id: 5580
Gene Symbol: PRKCD
PRKCD 		0.010 Biomarker disease BEFREE A prospective study of all 93 eclamptic women admitted to a general hospital in Somali regional state, Ethiopia was conducted between May 1, 2014 and April 30, 2015 using a structured questionnaire which included socio-demographic data, antenatal visit status, distance of nearest maternal health facility, timing of convulsions, questions related to symptoms preceding seizures; health care seeking for the symptoms and time interval from prodromal symptoms to the diagnosis of eclampsia. 28288576 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.030 GeneticVariation disease BEFREE A significantly higher C/C genotype frequency of IL-10 (-592 and -819) was observed in the PE patients than in the control groups. 18705845 2008
Entrez Id: 2147
Gene Symbol: F2
F2 		0.020 GeneticVariation disease BEFREE A strong independent association between the prothrombin G20210A gene mutation and pre-eclampsia has been reported in an Italian population. 11093048 2000
Entrez Id: 4153
Gene Symbol: MBL2
MBL2 		0.030 GeneticVariation disease BEFREE A trend was found between MBL genotype groups B and C and severe pre-eclampsia or eclampsia. 18082567 2007
Entrez Id: 2153
Gene Symbol: F5
F5 		0.050 GeneticVariation disease BEFREE Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia. 12628278 2003
Entrez Id: 7056
Gene Symbol: THBD
THBD 		0.010 GeneticVariation disease BEFREE Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia. 12628278 2003