Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.050 Biomarker disease BEFREE The current study showed that PLGF, VEGF, and HIF-1α are involved in the pathophysiology of pre-eclampsia. 29455633 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.050 Biomarker disease BEFREE We review the literature on the possible role of hypoxia in the etiology of IH, in particular, (1) the role of hypoxia inducible factor-1α (HIF-1α) and its downstream targets including GLUT-1 and VEGF; (2) the pathophysiological link between IH and retinopathy of prematurity; (3) hypoxic events in the early life including placental insufficiency, pre-eclampsia and low birthweight that have the potential to promote hypoxic stress; and (4) the evidence supporting the development of IH independent of HIF-1α. 26940670 2016
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.050 GeneticVariation disease BEFREE Our results suggest that the HIF-1α gene polymorphisms are not associated with the development of pre-eclampsia in the studied Korean women population. 21979130 2012
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.050 GeneticVariation disease BEFREE Here we studied whether two single nucleotide sequence variants, c.1744 C>T that changes residue 582 of HIF-1alpha from proline to serine (P582S) and c.1762 G>A that changes residue 588 of HIF-1alpha from alanine to threonine (A588T) in the exon 12 of the HIF1A gene, are associated with pre-eclampsia. 18980686 2008
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.050 AlteredExpression disease BEFREE We speculate that if oxygen tension fails to increase, or trophoblasts do not detect this increase, HIF-1alpha and TGFbeta3 expression remain high, resulting in shallow trophoblast invasion and predisposing the pregnancy to pre-eclampsia. 10831118 2000