| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | The HMWA levels in patients with eclampsia in the secondary pregnancy was significantly lower than those in patients without eclampsia, and the leptin levels in patients with eclampsia were significantly increased. | 29109760 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | In a prospective study of pregnant women with type 1 diabetes, we measured plasma levels of adipokines known to be associated with insulin resistance: leptin, fatty acid binding protein 4 (FABP4), adiponectin (total and high molecular weight [HMW]; also known as high molecular mass), retinol binding protein 4 (RBP4) and resistin and evaluated associations with the subsequent development of pre-eclampsia. | 28875223 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Hypomethylation of the LEP gene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia. | 23274423 | 2013 | ||||
|
0.070 | Biomarker | disease | BEFREE | Increased leptin concentration can definitely contribute to the prediction of pre-eclampsia in lean women, but this is not the case in overweight women. | 20050765 | 2010 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestational hypertension, proteinuria and various measures of reduced fetal growth ) in the Czech pre-eclamptic population. | 18958929 | 2008 | ||||
|
0.070 | Biomarker | disease | BEFREE | The up-regulated genes included leptin and inhibin A, which are well-known biological markers for pre-eclampsia, as well as FLT1, which was recently proved to be tightly linked with the etiology of this disease. | 16860862 | 2007 | ||||
|
0.070 | Biomarker | disease | BEFREE | The objective of this study was to investigate the relationship between placental leptin gene expression, placental leptin protein concentration and maternal plasma leptin concentration among control pregnant women, women with pre-eclampsia and women with growth-restricted infants. | 16870954 | 2006 |