Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE The polymorphisms of eNOS G894T and ET-2 A985G genes are correlated with the occurrence of eclampsia. 31486478 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 Biomarker disease BEFREE The mechanisms may include the following pathways: [TGFB1 or TNFA]-[IL1B]-[pre-eclampsia]; [TNFA or INS]-[NOS3]-[pre-eclampsia]; [INS]-[HSPA4 or CLU]-[pre-eclampsia]; [ACE]-[MTHFR]-[pre-eclampsia]. 25879409 2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE The presence of at least one polymorphic allele for NOS3 T-786C was also associated with the occurrence of eclampsia or HELLP syndrome among preeclamptic women. 26317342 2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE Glu298Asp polymorphism in the eNOS gene could be an individual's risk factor and may modulate progression to an eclampsia complication of preeclampsia in the Turkish population. 21793998 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE As observed in this study Glu298Asp eNOS gene polymorphism did not showed significant association with pre-eclampsia. 20047583 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 Biomarker disease BEFREE We demonstrate in a large Caucasian population that maternal polymorphisms of the NOS3 gene are not related to clinical markers of pre-eclampsia. 18463669 2008
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE However, previous studies of the association between pre-eclampsia and polymorphisms of single genes encoding renin-angiotensin system components and endothelial nitric oxide synthase have yielded conflicting results. 17520398 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 Biomarker disease BEFREE Endothelial nitric oxide synthase gene influences the risk of pre-eclampsia, the recurrence of negative pregnancy events, and the maternal-fetal flow. 16915032 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE Among these are the angiotensinogen (AGT) gene variant Met235Threo, which has been associated with pre-eclampsia and the endothelial nitric oxide synthase (eNOS) polymorphism Glu298Asp, which has been associated with both pre-eclampsia and abruptio placentae, a condition that often co-exists with pre-eclampsia. 16059745 2005
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 AlteredExpression disease BEFREE Placental endothelial nitric oxide synthase localization and expression in normal human pregnancy and pre-eclampsia. 12859429 2004
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE Carriers of eNOS Asp298 may be at risk of developing pre-eclampsia. 12530931 2003
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 AlteredExpression disease BEFREE VLDL, LDL and HDL from women with pre-eclampsia did not affect endothelial cell synthesis of endothelin 1 or expression of NOS3 mRNA differently from lipoproteins from normal pregnant women. 10585897 1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 GeneticVariation disease BEFREE The linkage results support the possibility that a susceptibility locus for pre-eclampsia resides in the 7q36 region, however, there is no definitive evidence to support the notion that the eNOS gene itself is responsible for susceptibility to pre-eclampsia. 10647900 1999
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.200 Biomarker disease HPO