Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Abundant corneocyte surface protrusions, observed in patients with atopic dermatitis with filaggrin loss-of-function mutations, are inversely associated with levels of natural moisturizing factors (NMFs) in the stratum corneum. 31479664 2020
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 Biomarker disease BEFREE Filaggrin remains a very important player in the pathogenesis of atopic dermatitis and allergic disease. 31622670 2020
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE The presence of loss-of-function mutations in the filaggrin gene (FLG) is the main predisposing factor for AD FLG mutations show ethnic and geographical variations, even between European populations. 31637781 2020
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 Biomarker disease BEFREE Then, we assessed the proliferation and the production of the Th22 chemokines CCR4 and CCR10 by ICOSL-stimulated AD peripheral blood mononuclear cells (PBMCs) as well as their effects on keratinocyte filaggrin production. 31090221 2020
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE This case suggests that the FLG mutation and IgE-mediated sensitization are not necessary to induce AD skin manifestation. 31773767 2020
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Filaggrin (FLG) loss of function variants have been associated with the onset and severity of atopic dermatitis and are the most common genetic association with AD. 31372728 2020
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE The discovery of the filaggrin gene was important in the emerging model for AD pathogenesis, combining skin barrier function with adaptive and innate immunity. 31203284 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 AlteredExpression disease BEFREE Filaggrin expression was fully maintained in the AD-like models, but only partially in psoriasis-like conditions after pretreatment with tofacitinib. 30357932 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Current research has shown sensitization can occur through impaired skin such as those with eczema and a filaggrin mutation. 30159849 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE The contribution of filaggrin gene mutations to atopic dermatitis has increased our appreciation of the role barrier perturbations play in inflammatory dermatoses. 30681811 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Although <i>FLG</i> null mutations are strongly associated with AD, they are not sufficient to induce the disease. 31121896 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE FLG loss-of-function mutations are the strongest genetic risk factors for human atopic dermatitis. 30199656 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 AlteredExpression disease BEFREE Filaggrin expression and TEWL were increased in skin lesions of AD-like GVHD and LP-like GVHD. 31404571 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE FLG loss-of-function mutations were significantly associated with AD onset in infancy (≤2 years) (P < 0.001, OR 3.54, 95% CI 1.88-6.65), but not with AD onset in childhood (≥3 years) (P = 0.981, OR 0.99, 95% CI 0.29-3.36), and none of the children in the present cohort who developed AD at 5 years of age or later carried FLG loss-of-function mutations. 31249362 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 AlteredExpression disease BEFREE Recent studies have identified a crucial role for the aryl hydrocarbon receptor (AHR) in controlling the gene expression of filaggrin and other skin barrier proteins, suggesting an underlying association between AHR and AD pathogenesis. 30499126 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Children with early, late transient and persistent eczema more often had a filaggrin mutation or additional risk alleles (range OR: 1.07, 95%CI 1.02-1.12 and OR 2.21, 95%CI 1.39-3.50). 30869802 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Major limitations of published studies were low numbers of individuals with AD and FLG loss-of-function mutations and exposure to specific environmental factors (n=5 to 94), and variation in exposure definitions. 31794059 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Overall, these results show that Tregs may participate into AD pathogenesis and that FLG null mutations exert further modifications on specific subpopulations of circulating Tregs. 30515983 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 AlteredExpression disease BEFREE Multiple factors are associated with colonization of AD skin by <i>S. aureus</i>, including the strength of <i>S. aureus</i>-corneocyte adhesion, deficiency of antimicrobial peptides, decreased levels of filaggrin and filaggrin degradation products, overexpressed Th2/Th17 cytokines, microbial dysbiosis and altered lipid profiles.<i>S. aureus</i> colonization on AD skin causes skin barrier dysfunction through virulence factors such as superantigens (toxins), enzymes and other proteins. 31332972 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 AlteredExpression disease BEFREE OR10G7 expression was significantly increased in skin biopsy specimens from patients with AD compared with those from HC subjects (P = .01) and inversely correlated with FLG-1 expression (P = .009). 30445058 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 GeneticVariation disease BEFREE Recent investigations implicate disease severity and persistence, age of onset, parental atopic history, filaggrin (FLG) mutations, polysensitization, and the nonrural environment among risk factors for development of multiple atopic comorbidities in young children with AD. 30458183 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 AlteredExpression disease BEFREE Studies have shown that AD harbors different endotypes across different age groups and ethnicities and according to IgE levels and filaggrin mutation status. 30612663 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 Biomarker disease BEFREE Filaggrin and the proportion of ω-hydroxy fatty acid sphingosine ceramide content in nonlesional skin of children with AD <i>FA</i>+ were substantially lower than in AD <i>FA</i>- and NA skin. 30787169 2019
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.700 AlteredExpression disease BEFREE These results suggest that β-carotene reduces skin inflammation through the suppressed expression of inflammatory factors or the activity of MMPs as well as the promotion of filaggrin expression in AD-like skin. 31292344 2019