We used quantitative chemical proteomics to reveal a ritanserin-dependent kinase network that includes key mediators of lipid [diacylglycerol kinase <i>α</i>, phosphatidylinositol 4-kinase <i>β</i>] and protein [feline encephalitis virus-related kinase, rapidly accelerated fibrosarcoma (RAF)] signaling, metabolism [eukaryotic elongation factor 2 kinase, eukaryotic translation initiation factor 2-<i>α</i> kinase 4], and DNA damage response [tousled-like kinase 2] to broadly kill lung tumor cell types.