Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation.
In severe HFMD, all levels (except IL-8 and IL-4) were higher in patients with encephalitis plus pulmonary edema than in those with encephalitis alone (<i>P</i> < 0.05).
RESULTS IL-4rs2227283 and IL-10 rs1800871 have no correlation in with risk of virus-induced encephalitis (both P>0.05) GA and AA genotypes were related to IL-4rs2227288 and GT, while TT and GT + TT genotypes were related to IL-10 rs1800872.
In patients with severe HFMD, all expression levels (with the exception of IL‑8 and IL‑4) were increased in patients with encephalitis plus pulmonary edema compared with those with encephalitis alone.