×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
0.100
GeneticVariation
disease
BEFREE
SLE -associated IRF5 haplotypes were correlated with the expression data and with the best cis-regulatory models.
21627826
2011
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility.
20166876
2010
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
Using a high-resolution melting curve analysis, we assessed the prevalence of TNF-α -308 G/A SNP in SLE patients (n = 262) and controls (n = 528) in a Polish population.
25661739
2015
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
Meta-analysis of TNF-α promoter -308A/G polymorphism and SLE susceptibility in Asian populations.
20333386
2011
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
Genetic susceptibility to SLE is associated with TNF-alpha gene polymorphism -863, but not -308 and -238, in Thai population.
18001298
2007
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility.
16418737
2006
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
The combined frequencies of IL-10 A/T/A haplotype and TNF-alpha G-G genotype were significantly increased in SLE patients.
20576226
2010
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
Stratification of patients suggested that DRB*1501 and TNF a11 frequencies were higher in SLE patients with renal disease and TNF a2 and b 3 frequencies in those without, although these differences did not reach statistical significance.
9543565
1998
×
Entrez Id:
3586
Gene Symbol:
IL10
IL10
0.090
GeneticVariation
disease
BEFREE
Preferential binding to Elk-1 by SLE -associated IL10 risk allele upregulates IL10 expression.
24130510
2013
×
Entrez Id:
3586
Gene Symbol:
IL10
IL10
0.090
GeneticVariation
disease
BEFREE
Influence of Atg5 mutation in SLE depends on functional IL-10 genotype.
24205307
2013
×
Entrez Id:
3586
Gene Symbol:
IL10
IL10
0.090
GeneticVariation
disease
BEFREE
Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10 ) conferred the susceptibility to SLE .
30171347
2018
×
Entrez Id:
3586
Gene Symbol:
IL10
IL10
0.090
GeneticVariation
disease
BEFREE
Furthermore, the IL-10 AA genotype is associated with reduced ratio of atheroprotective to atherogenic cytokines in SLE patients with CVD.
15530917
2004
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.080
GeneticVariation
disease
BEFREE
Association of IL -6 -174 G>C polymorphism with the risk of SLE among south Indians: evidence from case-control study and meta-analysis.
28530463
2017
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
0.080
GeneticVariation
disease
BEFREE
The frequency of the interleukin-6 GG and GC genotypes was significantly higher in SLE patients than in controls, and a significantly higher percentage of the G vs C alleles between patients and controls was revealed (odds ratio 2.53, 95% confidence interval 1.37-4.65, chi-squared test 8.16, P < 0.05).
15449022
2005
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
0.070
GeneticVariation
disease
BEFREE
Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility.
22707193
2012
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
0.070
GeneticVariation
disease
BEFREE
The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE .
12460032
2002
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
0.070
GeneticVariation
disease
BEFREE
The aim of the study was to investigate the role of the MCP-1 gene polymorphism as early predictors of the development of glomerulonephropathy in SLE patients.
26429331
2015
×
Entrez Id:
3458
Gene Symbol:
IFNG
IFNG
0.060
GeneticVariation
disease
BEFREE
Interestingly, we found the combined effect between the G/C genotype of IL-18 (-137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56-291.66, P = 0.004).
19031096
2009
HLA-DRB1
0.060
GeneticVariation
disease
BEFREE
SLE -SS patients had a high frequency of the DRB1 *0301 allele.
15022331
2004
HLA-DRB1
0.060
GeneticVariation
disease
BEFREE
Analysis of the association of HLA-DRB1 , TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test.
11607787
2001
HLA-DRB1
0.060
GeneticVariation
disease
BEFREE
A highly significant increase in the frequency of DRB1 *1502 and DQB1*0501 was found in SLE patients compared with normal controls.
12028537
2002
HLA-DRB1
0.060
GeneticVariation
disease
BEFREE
Only the frequency of HLA-DRB1 *07 allele was higher in SLE patients than controls (odds ratio 2.92, 95% confidence interval 1.16-7.33), but the difference did not reach statistical significance when Bonferroni's adjustment procedure was performed.
15449022
2005
HLA-DRB1
0.060
GeneticVariation
disease
BEFREE
There was no significantly different distribution of HLA-DRB1 alleles between SLE patients with nephritis and without nephritis.
9157084
1996
×
Entrez Id:
3458
Gene Symbol:
IFNG
IFNG
0.060
GeneticVariation
disease
BEFREE
Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE .
17713715
2007
×
Entrez Id:
3606
Gene Symbol:
IL18
IL18
0.050
GeneticVariation
disease
BEFREE
Impact of functional IL-18 polymorphisms on genetic predisposition and diverse clinical manifestations of the disease in Indian SLE patients.
30857465
2019