Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3663
Gene Symbol: IRF5
IRF5 		0.100 GeneticVariation disease BEFREE SLE-associated IRF5 haplotypes were correlated with the expression data and with the best cis-regulatory models. 21627826 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility. 20166876 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE Using a high-resolution melting curve analysis, we assessed the prevalence of TNF-α-308 G/A SNP in SLE patients (n = 262) and controls (n = 528) in a Polish population. 25661739 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE Meta-analysis of TNF-α promoter -308A/G polymorphism and SLE susceptibility in Asian populations. 20333386 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE Genetic susceptibility to SLE is associated with TNF-alpha gene polymorphism -863, but not -308 and -238, in Thai population. 18001298 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. 16418737 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE The combined frequencies of IL-10 A/T/A haplotype and TNF-alpha G-G genotype were significantly increased in SLE patients. 20576226 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 GeneticVariation disease BEFREE Stratification of patients suggested that DRB*1501 and TNF a11 frequencies were higher in SLE patients with renal disease and TNF a2 and b 3 frequencies in those without, although these differences did not reach statistical significance. 9543565 1998
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.090 GeneticVariation disease BEFREE Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. 24130510 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.090 GeneticVariation disease BEFREE Influence of Atg5 mutation in SLE depends on functional IL-10 genotype. 24205307 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.090 GeneticVariation disease BEFREE Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. 30171347 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.090 GeneticVariation disease BEFREE Furthermore, the IL-10 AA genotype is associated with reduced ratio of atheroprotective to atherogenic cytokines in SLE patients with CVD. 15530917 2004
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.080 GeneticVariation disease BEFREE Association of IL -6 -174 G>C polymorphism with the risk of SLE among south Indians: evidence from case-control study and meta-analysis. 28530463 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.080 GeneticVariation disease BEFREE The frequency of the interleukin-6 GG and GC genotypes was significantly higher in SLE patients than in controls, and a significantly higher percentage of the G vs C alleles between patients and controls was revealed (odds ratio 2.53, 95% confidence interval 1.37-4.65, chi-squared test 8.16, P < 0.05). 15449022 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.070 GeneticVariation disease BEFREE Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility. 22707193 2012
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.070 GeneticVariation disease BEFREE The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE. 12460032 2002
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.070 GeneticVariation disease BEFREE The aim of the study was to investigate the role of the MCP-1 gene polymorphism as early predictors of the development of glomerulonephropathy in SLE patients. 26429331 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.060 GeneticVariation disease BEFREE Interestingly, we found the combined effect between the G/C genotype of IL-18 (-137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56-291.66, P = 0.004). 19031096 2009
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.060 GeneticVariation disease BEFREE SLE-SS patients had a high frequency of the DRB1*0301 allele. 15022331 2004
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.060 GeneticVariation disease BEFREE Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. 11607787 2001
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.060 GeneticVariation disease BEFREE A highly significant increase in the frequency of DRB1*1502 and DQB1*0501 was found in SLE patients compared with normal controls. 12028537 2002
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.060 GeneticVariation disease BEFREE Only the frequency of HLA-DRB1*07 allele was higher in SLE patients than controls (odds ratio 2.92, 95% confidence interval 1.16-7.33), but the difference did not reach statistical significance when Bonferroni's adjustment procedure was performed. 15449022 2005
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.060 GeneticVariation disease BEFREE There was no significantly different distribution of HLA-DRB1 alleles between SLE patients with nephritis and without nephritis. 9157084 1996
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.060 GeneticVariation disease BEFREE Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE. 17713715 2007
Entrez Id: 3606
Gene Symbol: IL18
IL18 		0.050 GeneticVariation disease BEFREE Impact of functional IL-18 polymorphisms on genetic predisposition and diverse clinical manifestations of the disease in Indian SLE patients. 30857465 2019