Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 151112
Gene Symbol: ZSWIM2
ZSWIM2
0.010 GeneticVariation disease BEFREE SLE phenotypes were stratified according to the MEX-SLEDAI scores into two subgroups (<or=10 and >10), and then according to renal disorder and neurological disorder, aiming to minimize any loss of power associated with disease heterogeneity. 19399503 2009
Entrez Id: 7535
Gene Symbol: ZAP70
ZAP70
0.010 AlteredExpression disease BEFREE The gene expressions of Blk and ZAP70 were significantly lower in SLE patients who had flares according to the SELENA-SLEDAI flare index when compared to those in others (p values 0.01 and 0.017). 27864698 2017
Entrez Id: 286046
Gene Symbol: XKR6
XKR6
0.010 GeneticVariation disease BEFREE Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort. 29967481 2018
Entrez Id: 7503
Gene Symbol: XIST
XIST
0.010 AlteredExpression disease BEFREE SLE T cells also have altered expression of XIST RNA interactome genes, accounting for perturbations of Xi epigenetic features. 30944248 2019
Entrez Id: 6375
Gene Symbol: XCL1
XCL1
0.010 Biomarker disease BEFREE ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells. 27249108 2016
Entrez Id: 65125
Gene Symbol: WNK1
WNK1
0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.010 AlteredExpression disease BEFREE Furthermore, a higher CD3Z methylation level was significantly correlated with a higher SLE disease activity index and more severe clinical manifestations, such as proteinuria, haemolytic anaemia and thrombocytopenia, whereas VHL hypermethylation was not. 27940592 2017
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.010 GeneticVariation disease BEFREE No association of VDR gene BsmI polymorphisms with SLE disease activity index (SLEDAI), SLE damage score and major organ involvement was detected. 20473502 2010
Entrez Id: 7345
Gene Symbol: UCHL1
UCHL1
0.010 AlteredExpression disease BEFREE CSF UCH-L1 levels were significantly positively correlated with SLE disease activity index and overlap number of NPSLE manifestations. 30418114 2019
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
0.040 GeneticVariation disease BEFREE Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. 19440814 2009
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
0.040 GeneticVariation disease BEFREE Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families. 17384181 2007
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
0.040 GeneticVariation disease BEFREE SLE protection was associated with TYK2 risk infection variants affecting residually its catalytic domain, rs12720356 (OR = 0.308; p = 0.041) and rs34536443 (OR = 0.370; p = 0.034), but not with rs2304256, rs12720270, and rs280500. 31434951 2019
Entrez Id: 7297
Gene Symbol: TYK2
TYK2
0.040 GeneticVariation disease BEFREE Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. 30171347 2018
Entrez Id: 706
Gene Symbol: TSPO
TSPO
0.010 Biomarker disease BEFREE Instead, there was a significant decrease in TSPO distribution in the cerebellum and hippocampus of SLE patients, as compared to healthy controls. 27387599 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.020 Biomarker disease BEFREE Heritable factors shape natural human IgM reactivity to Ro60/SS-A and may predispose for SLE-associated IgG anti-Ro and anti-La autoantibody production. 16006098 2005
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21
0.020 GeneticVariation disease BEFREE The rs10516487 and rs17266594 polymorphisms were significantly associated with high-titre ANA (≥1 : 320) and production of anti-SSA antibodies in SLE patients compared with the control subjects. 21078628 2011
Entrez Id: 54210
Gene Symbol: TREM1
TREM1
0.010 Biomarker disease BEFREE Utility of neutrophil CD64 and serum TREM-1 in distinguishing bacterial infection from disease flare in SLE and ANCA-associated vasculitis. 30446886 2019
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.010 Biomarker disease BEFREE The ancestral Ala471 CD5 allele confers lymphocyte hyper-responsiveness to TCR/CD3 cross-linking and is associated with nephritis in SLE patients. 25402503 2014
Entrez Id: 7292
Gene Symbol: TNFSF4
TNFSF4
0.030 Biomarker disease BEFREE B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis. 28818832 2017
Entrez Id: 7292
Gene Symbol: TNFSF4
TNFSF4
0.030 Biomarker disease BEFREE Our data firstly replicated the association of TNFSF4 with renal disorder in SLE patients in the Chinese population, which supported that TNFSF4 may act as a marker of lupus nephritis. 23936824 2013
Entrez Id: 7292
Gene Symbol: TNFSF4
TNFSF4
0.030 Biomarker disease BEFREE OX40L/OX40 axis impairs follicular and natural Treg function in human SLE. 30568041 2018
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 AlteredExpression disease BEFREE Expression of B-cell activating factor (BAFF) binding receptors (BBRs) and survival of RP105(-) B cells from SLE patients were examined. 20097906 2010
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 GeneticVariation disease BEFREE B cell alterations during BAFF inhibition with belimumab in SLE. 30593436 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 AlteredExpression disease BEFREE Excessive miR-152-3p Results in Increased BAFF Expression in SLE B-Cells by Inhibiting the KLF5 Expression. 31178864 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 AlteredExpression disease BEFREE We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity. 30626389 2019