Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
0.040 GeneticVariation disease BEFREE Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families. 12215901 2002
Entrez Id: 1636
Gene Symbol: ACE
0.040 GeneticVariation disease BEFREE Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE. 12043886 2002
Entrez Id: 1636
Gene Symbol: ACE
0.040 GeneticVariation disease BEFREE No single ACE genotype was consistently associated with subsets of SLE patients. 16830877 2006
Entrez Id: 1636
Gene Symbol: ACE
0.040 GeneticVariation disease BEFREE However, an increased frequency ofDD genotype (ACE I/D) was observed in SLE patients with LN who progressed to CRF compared to healthy controls (DD 60%, DI 26.7%, II 13.3% versus 27.7%, 60% and 12.3%, respectively; chi2 = 6.299, P = 0.0429). 15934435 2005
Entrez Id: 49
Gene Symbol: ACR
0.010 GeneticVariation disease BEFREE This was a cross-sectional study.Participants were 123 women with SLE according to the ACR criteria and 132 age-matched healthy women (median = 45 (IQR = 34-54) years). 31126410 2019
Entrez Id: 9370
Gene Symbol: ADIPOQ
0.010 AlteredExpression disease BEFREE SLE disease activity and complement components may suggest regulatory effect of adipokines (adiponectin and leptin) on disease pathogenesis. 30098476 2018
Entrez Id: 133
Gene Symbol: ADM
0.010 AlteredExpression disease BEFREE In addition, IL-6 mRNA levels positively correlated and AM mRNA levels negatively correlated with SLE disease activity index and laboratory findings, such as blood urea nitrogen, serum creatinine, 50% haemolytic unit of complement and urinary excretion of protein over 24 h. Furthermore, IL-6 mRNA levels were negatively correlated with AM mRNA levels within the same LN patients. 11422212 2001
Entrez Id: 183
Gene Symbol: AGT
0.010 Biomarker disease BEFREE The angiotensin II receptor blocker (ARB) olmesartan has been recently associated with sprue-like enteropathy (SLE), a gastrointestinal condition characterized by intestinal malabsorption (IM) and severe diarrhea. 29457309 2018
Entrez Id: 196
Gene Symbol: AHR
0.010 Biomarker disease BEFREE Association between the ratio of aryl hydrocarbon receptor (AhR) in Th17 cells to AhR in Treg cells and SLE skin lesions. 30743201 2019
Entrez Id: 57379
Gene Symbol: AICDA
0.020 Biomarker disease BEFREE Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE. 25634361 2015
Entrez Id: 57379
Gene Symbol: AICDA
0.020 AlteredExpression disease BEFREE Downregulated expression of miR-155, miR-17, and miR-181b, and upregulated expression of activation-induced cytidine deaminase and interferon-α in PBMCs from patients with SLE. 25775145 2015
Entrez Id: 9447
Gene Symbol: AIM2
0.020 Biomarker disease BEFREE Absent in Melanoma 2 proteins in SLE. 28062222 2017
Entrez Id: 9447
Gene Symbol: AIM2
0.020 AlteredExpression disease BEFREE G-MDSCs produce high levels of ROS (reactive oxygen species) through increasing gp91(phox) expression, and activated TLR2 (Toll-like receptor 2) and AIM2 (absent in melanoma 2) inflammasome in M-MDSCs lead to IL-1β (interleukin 1β) expression in diseased MRL/lpr mice and high-disease-activity SLE patients. 27231253 2016
Entrez Id: 10541
Gene Symbol: ANP32B
0.010 Biomarker disease BEFREE Post Hoc Analysis of the Phase II/III APRIL-SLE Study: Association Between Response to Atacicept and Serum Biomarkers Including BLyS and APRIL. 27390168 2017
Entrez Id: 8639
Gene Symbol: AOC3
0.010 Biomarker disease BEFREE This study investigated the expression of vascular adhesion protein-1 (VAP-1) in SLE patients with conjunctivitis and the relationship between VAP-1 and other proteins in the onset of the disease. 31819770 2019
Entrez Id: 104326055
Gene Symbol: APOA1-AS
0.010 Biomarker disease BEFREE To quantify the expression level of three lncRNAs which are known to be relevant to atherosclerosis (ANRIL, NOS3-AS, and APOA1-AS) in SLE patients and to assess their relationship with atherogenic and inflammatory biomarkers. 30128915 2018
Entrez Id: 348
Gene Symbol: APOE
0.010 GeneticVariation disease BEFREE Reduced apo B levels in RA and SLE according to the cumulative dose of chloroquine 2/3 APO E genotype in a subset of SLE patients were observed. 11922198 2002
Entrez Id: 350
Gene Symbol: APOH
0.010 GeneticVariation disease BEFREE Val/Leu247 polymorphism of β2-glycoprotein I and thrombosis in Chinese patients with SLE. 24661363 2015
Entrez Id: 55937
Gene Symbol: APOM
0.010 AlteredExpression disease BEFREE Since apoM plasma levels decrease during inflammatory conditions, our aim was also to determine the impact of SLE disease activity on apoM plasma levels. 31046824 2019
Entrez Id: 361
Gene Symbol: AQP4
0.010 Biomarker disease BEFREE Serum AQP4-IgG was detected in 2 of 30 (6.7%) neuropsychiatric SLE (NPSLE) patients both of whom had myelitis and antiphospholipid syndrome; one patient also had myasthenia gravis.None had MOG-IgG. 28326889 2018
Entrez Id: 397
Gene Symbol: ARHGDIB
0.010 Biomarker disease BEFREE Recently, we described the presence of autoantibodies against D4GDI (Rho GDP dissociation inhibitor beta, ARHGDIB) in the serum of a large subset of SLE patients, and we observed that anti-D4GDI antibodies activated the cytoskeleton remodeling of lymphocytes by inhibiting D4GDI and allowing the upregulation of Rho GTPases, such as Rac1. 31262358 2019
Entrez Id: 1820
Gene Symbol: ARID3A
0.020 Biomarker disease BEFREE SLE HSPCs with high numbers of ARID3a(+) cells also more readily generated autoantibody-producing cells than HSPCs with lower levels of ARID3a in a humanized mouse model. 25535283 2015
Entrez Id: 1820
Gene Symbol: ARID3A
0.020 Biomarker disease BEFREE New Frontiers: ARID3a in SLE. 31554207 2019
Entrez Id: 9474
Gene Symbol: ATG5
0.010 GeneticVariation disease BEFREE Influence of Atg5 mutation in SLE depends on functional IL-10 genotype. 24205307 2013
Entrez Id: 1822
Gene Symbol: ATN1
0.010 Biomarker disease BEFREE The NOD mouse as a model of SLE. 11681493 2001