Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10603
Gene Symbol: SH2B2
SH2B2
0.020 Biomarker disease BEFREE .Platelet size is decreased in SLE patients and associated with microparticle formation and APS. 28031442 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.020 Biomarker disease BEFREE .Platelet size is decreased in SLE patients and associated with microparticle formation and APS. 28031442 2017
Entrez Id: 442900
Gene Symbol: MIR326
MIR326
0.010 AlteredExpression disease BEFREE 1.The level of miR-326 was significantly higher in Treg cells from SLE patients [1.98(0.592,6.148)] than that in healthy controls [0.921(0.345, 1.879)] (p = 0.032). 26861134 2016
Entrez Id: 2113
Gene Symbol: ETS1
ETS1
0.030 GeneticVariation disease BEFREE 3' polymorphisms of ETS1 are associated with different clinical phenotypes in SLE. 10874305 2000
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.040 AlteredExpression disease BEFREE 3H - TdR incorporation of SLE B cells without stimuli (P<0.001) and with CD40L-LZ stimulation (P<0.05) were significantly lower in SLE patients compared with normal controls. 10342716 1999
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
0.040 AlteredExpression disease BEFREE SLE and normal T cells pretreated with estradiol and cultured with ionomycin for 2 h to activate calcineurin showed no significant differences in CD40L mRNA. 11764210 2001
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 64689
Gene Symbol: GORASP1
GORASP1
0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 6857
Gene Symbol: SYT1
SYT1
0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 65125
Gene Symbol: WNK1
WNK1
0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 6631
Gene Symbol: SNRPC
SNRPC
0.010 Biomarker disease BEFREE SLE patient sera were positive for reactivity to: U1snRNP-C, 4/15 (27%); alpha-enolase, 1/15 (7%); RPS20, 3/15 (20%); RPS13, 1/15 (7%); PIC1, 1/15 (7%); and MRG15, 2/15 (13%). 12379236 2002
Entrez Id: 3151
Gene Symbol: HMGN2
HMGN2
0.010 Biomarker disease BEFREE SLE sera positive for HMG-17 had also cross reactivity with H1, and following the same procedure as before we received HMG-17 specific SLE autoantibodies and anti-HMG-17/H1 autoantibodies. 12523645 2002
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.060 GeneticVariation disease BEFREE SLE-SS patients had a high frequency of the DRB1*0301 allele. 15022331 2004
Entrez Id: 129831
Gene Symbol: RBM45
RBM45
0.020 GeneticVariation disease BEFREE SLE-SS patients had a high frequency of the DRB1*0301 allele. 15022331 2004
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
0.010 Biomarker disease BEFREE SLE T cells and T cells treated with DNA methyltransferase inhibitors and ERK pathway inhibitors overexpress CD70. 15188362 2004
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
0.010 Biomarker disease BEFREE SLE T cells and T cells treated with DNA methyltransferase inhibitors and ERK pathway inhibitors overexpress CD70. 15188362 2004
Entrez Id: 970
Gene Symbol: CD70
CD70
0.030 AlteredExpression disease BEFREE SLE T cells and T cells treated with DNA methylation inhibitors overexpressed CD70 and overstimulated B cell IgG production. 15188362 2004
Entrez Id: 4938
Gene Symbol: OAS1
OAS1
0.010 AlteredExpression disease BEFREE SLE complicated with infections have higher OAS1 expression level (P=0.002), lower OASL (P=0.004), and equivalent OAS2 (P=0.135), when compared with those of normal controls. 16565890 2007
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 AlteredExpression disease BEFREE SLE synovial biopsy tissue displayed a significant down-regulation of genes involved in extracellular matrix (ECM) homeostasis and a significant up-regulation of interferon-inducible (IFI) genes. 17469140 2007
Entrez Id: 948
Gene Symbol: CD36
CD36
0.010 AlteredExpression disease BEFREE SLE patient plasma markedly stimulated expression of CD36 message in a dose-dependent fashion in THP-1 human monocytes. 19144874 2009
Entrez Id: 151112
Gene Symbol: ZSWIM2
ZSWIM2
0.010 GeneticVariation disease BEFREE SLE phenotypes were stratified according to the MEX-SLEDAI scores into two subgroups (<or=10 and >10), and then according to renal disorder and neurological disorder, aiming to minimize any loss of power associated with disease heterogeneity. 19399503 2009
Entrez Id: 3665
Gene Symbol: IRF7
IRF7
0.010 Biomarker disease BEFREE SLE-associated autoantibodies can stimulate IFNalpha production through the Toll-like receptor/IRF7 pathway. 20112359 2010
Entrez Id: 814
Gene Symbol: CAMK4
CAMK4
0.010 AlteredExpression disease BEFREE SLE T cells express high levels of calcium/calmodulin-dependent protein kinase type IV (CaMKIV), which translocates to the nucleus upon engagement of the T cell receptor-CD3 complex and accounts for abnormal T cell function. 20954187 2011
Entrez Id: 820
Gene Symbol: CAMP
CAMP
0.010 Biomarker disease BEFREE SLE NETs contain DNA as well as large amounts of LL37 and HMGB1, neutrophil proteins that facilitate the uptake and recognition of mammalian DNA by plasmacytoid DCs (pDCs). 21389264 2011