Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 GeneticVariation disease BEFREE The aim of the study was to investigate the role of the MCP-1 gene polymorphism as early predictors of the development of glomerulonephropathy in SLE patients. 26429331 2015
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 Biomarker disease BEFREE Significant increases in IFN score (p < 0.0001), STAT1 (p < 0.0001), miR-146a (p < 0.0005), CCL2 (p = 0.0047), and CXCL10 (p = 0.017), as well as a significant decrease in pri-miR-146a (p = 0.0002), were detected in the anemic SLE patient visits (n = 52) compared to non-anemic SLE visits (n = 128). 24292724 2014
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 GeneticVariation disease BEFREE Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility. 22707193 2012
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 AlteredExpression disease BEFREE Next were analyzed the correlations of TWEAK mRNA and protein to serum IL-10, MCP-1 and some laboratory parameters of SLE disease activity. 21163672 2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 GeneticVariation disease BEFREE The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE. 12460032 2002
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 Biomarker disease BEFREE The <i>STAT4</i> SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE. 29475858 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 AlteredExpression disease BEFREE We examined relative gene expression of tumour necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and serum levels of interleukin-17 (IL-17) and IL-23 and their association with SLEDAI (SLE disease activity index) score and organ manifestations in pSLE. 22759859 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.060 Biomarker disease BEFREE HLA-DRB1*15 confers susceptibility to juvenile SLE but is not associated with disease presentation: an Egyptian Study. 20380521 2010
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 GeneticVariation disease BEFREE Interestingly, we found the combined effect between the G/C genotype of IL-18 (-137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56-291.66, P = 0.004). 19031096 2009
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 AlteredExpression disease BEFREE SLE synovial biopsy tissue displayed a significant down-regulation of genes involved in extracellular matrix (ECM) homeostasis and a significant up-regulation of interferon-inducible (IFI) genes. 17469140 2007
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 GeneticVariation disease BEFREE Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE. 17713715 2007
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.060 GeneticVariation disease BEFREE Only the frequency of HLA-DRB1*07 allele was higher in SLE patients than controls (odds ratio 2.92, 95% confidence interval 1.16-7.33), but the difference did not reach statistical significance when Bonferroni's adjustment procedure was performed. 15449022 2005
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.060 GeneticVariation disease BEFREE SLE-SS patients had a high frequency of the DRB1*0301 allele. 15022331 2004
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.060 GeneticVariation disease BEFREE A highly significant increase in the frequency of DRB1*1502 and DQB1*0501 was found in SLE patients compared with normal controls. 12028537 2002
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.060 GeneticVariation disease BEFREE Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. 11607787 2001
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.060 GeneticVariation disease BEFREE There was no significantly different distribution of HLA-DRB1 alleles between SLE patients with nephritis and without nephritis. 9157084 1996
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.060 AlteredExpression disease BEFREE To determine the cellular expression and localization of interferon-gamma (IFN gamma)-inducible protein p16, a new antigen specificity of antinuclear antibodies (ANA), and to evaluate the prevalence of anti-p16, particularly in SLE patients. 7526871 1994
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.050 Biomarker disease BEFREE Peripheral neutrophil CD64 index combined with complement, CRP, WBC count and B cells improves the ability of diagnosing bacterial infection in SLE. 30712491 2019
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.050 GeneticVariation disease BEFREE Impact of functional IL-18 polymorphisms on genetic predisposition and diverse clinical manifestations of the disease in Indian SLE patients. 30857465 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE Mechanisms of action of low-dose IL-2 restoration therapies in SLE. 31450016 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 GeneticVariation disease BEFREE B cell alterations during BAFF inhibition with belimumab in SLE. 30593436 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 AlteredExpression disease BEFREE Excessive miR-152-3p Results in Increased BAFF Expression in SLE B-Cells by Inhibiting the KLF5 Expression. 31178864 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 AlteredExpression disease BEFREE We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity. 30626389 2019
Entrez Id: 10673
Gene Symbol: TNFSF13B
TNFSF13B
0.050 GeneticVariation disease BEFREE Susceptibility of BAFF-var allele carriers to severe SLE with occurrence of lupus nephritis. 31752784 2019
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients. 31484501 2019