Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.040 GeneticVariation disease BEFREE Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families. 12215901 2002
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.040 GeneticVariation disease BEFREE Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE. 12043886 2002
Entrez Id: 129831
Gene Symbol: RBM45
RBM45 		0.020 GeneticVariation disease BEFREE A highly significant increase in the frequency of DRB1*1502 and DQB1*0501 was found in SLE patients compared with normal controls. 12028537 2002
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.010 GeneticVariation disease BEFREE Reduced apo B levels in RA and SLE according to the cumulative dose of chloroquine 2/3 APO E genotype in a subset of SLE patients were observed. 11922198 2002
Entrez Id: 581
Gene Symbol: BAX
BAX 		0.010 AlteredExpression disease BEFREE A rise in the expression of the pro-apoptotic bax gene was detected specifically in the SLEV-infected K562 cells. 12111422 2002
Entrez Id: 3151
Gene Symbol: HMGN2
HMGN2 		0.010 Biomarker disease BEFREE SLE sera positive for HMG-17 had also cross reactivity with H1, and following the same procedure as before we received HMG-17 specific SLE autoantibodies and anti-HMG-17/H1 autoantibodies. 12523645 2002
Entrez Id: 5970
Gene Symbol: RELA
RELA 		0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 64689
Gene Symbol: GORASP1
GORASP1 		0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 6631
Gene Symbol: SNRPC
SNRPC 		0.010 Biomarker disease BEFREE SLE patient sera were positive for reactivity to: U1snRNP-C, 4/15 (27%); alpha-enolase, 1/15 (7%); RPS20, 3/15 (20%); RPS13, 1/15 (7%); PIC1, 1/15 (7%); and MRG15, 2/15 (13%). 12379236 2002
Entrez Id: 6857
Gene Symbol: SYT1
SYT1 		0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 65125
Gene Symbol: WNK1
WNK1 		0.010 AlteredExpression disease BEFREE SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2. 12027419 2002
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG 		0.040 AlteredExpression disease BEFREE Furthermore, CD40L expression on T cells upon activation was enhanced in SLE patients. 12673892 2003
Entrez Id: 1235
Gene Symbol: CCR6
CCR6 		0.020 Biomarker disease BEFREE The cell surface expression of the chemokine receptors CXCR5 and CCR6 was decreased in SLE patients compared with controls (P = 0.051 and P = 0.002, respectively). 14596426 2003
Entrez Id: 27352
Gene Symbol: SGSM3
SGSM3 		0.010 AlteredExpression disease BEFREE Constitutive up-regulated activity of MAP kinase is associated with down-regulated early p21Ras pathway in lymphocytes of SLE patients. 12367560 2003
Entrez Id: 6352
Gene Symbol: CCL5
CCL5 		0.010 AlteredExpression disease BEFREE The levels of the chemokines MIP-1alpha MCP-1, SDF-1alpha, IP-10 and RANTES were significantly elevated in SLE patients compared with controls. 14596426 2003
Entrez Id: 643
Gene Symbol: CXCR5
CXCR5 		0.010 Biomarker disease BEFREE The decrease of CXCR5 was confined to SLE patients with inactive disease (SLEDAI < 6) compared with active disease (SLEDAI > 6) and controls. 14596426 2003
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		0.010 Biomarker disease BEFREE Early p21Ras signalling was down-regulated in SLE patients with active disease as indicated by the decreased membrane/cytoplasmic (M/C) ratios of the p21Ras regulatory elements hSOS1 and p120GAP and by the non-responsiveness of these ratios to cellular stimulation. 12367560 2003
Entrez Id: 5921
Gene Symbol: RASA1
RASA1 		0.010 AlteredExpression disease BEFREE Levels of p21Ras stimulatory element hSOS1 but not p21Ras and its inhibitory element p120GAP were significantly decreased in SLE patients. 12367560 2003
Entrez Id: 6709
Gene Symbol: SPTAN1
SPTAN1 		0.010 Biomarker disease BEFREE Autoantibodies to alpha-fodrin in primary Sjögren's syndrome and SLE detected by an in vitro transcription and translation assay. 12673889 2003
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.090 GeneticVariation disease BEFREE Furthermore, the IL-10 AA genotype is associated with reduced ratio of atheroprotective to atherogenic cytokines in SLE patients with CVD. 15530917 2004
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.060 GeneticVariation disease BEFREE SLE-SS patients had a high frequency of the DRB1*0301 allele. 15022331 2004
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22 		0.050 GeneticVariation disease BEFREE Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. 15273934 2004
Entrez Id: 970
Gene Symbol: CD70
CD70 		0.030 AlteredExpression disease BEFREE SLE T cells and T cells treated with DNA methylation inhibitors overexpressed CD70 and overstimulated B cell IgG production. 15188362 2004
Entrez Id: 129831
Gene Symbol: RBM45
RBM45 		0.020 GeneticVariation disease BEFREE SLE-SS patients had a high frequency of the DRB1*0301 allele. 15022331 2004
Entrez Id: 139818
Gene Symbol: DOCK11
DOCK11 		0.010 Biomarker disease BEFREE An optimized IgG antibody capture ELISA (GAC-ELISA) with both WNV and SLEV VLPs was developed to circumvent the frequently observed higher background in the antigen-capture IgG-ELISA (ACG-ELISA). 15472331 2004