| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | disease | BEFREE | Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis. | 31130331 | 2019 | ||||
|
0.100 | Biomarker | disease | BEFREE | Genetic Versus Non-genetic Drivers of SLE: Implications of IRF5 Dysregulation in Both Roads Leading to SLE. | 30645688 | 2019 | ||||
|
0.100 | Biomarker | disease | BEFREE | IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors. | 28525378 | 2017 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE. | 23349905 | 2013 | ||||
|
0.100 | Biomarker | disease | BEFREE | SLE serum was identified as a trigger for IRF-5 nuclear accumulation; however, neither IFNα nor SLE immune complexes could induce nuclear localization. | 21968701 | 2012 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | SLE-associated IRF5 haplotypes were correlated with the expression data and with the best cis-regulatory models. | 21627826 | 2011 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. | 20479222 | 2010 | ||||
|
0.100 | Biomarker | disease | BEFREE | The significantly higher frequency of homozygote individuals for the risk haplotype among Mexican SLE patients could be the result of genetic admixture, and suggests the possibility that IRF5 could be involved in the more active disease and organ involvement known to occur among Mexican SLE patients. | 17476532 | 2007 | ||||
|
0.100 | Biomarker | disease | BEFREE | Opposed independent effects and epistasis in the complex association of IRF5 to SLE. | 17568788 | 2007 | ||||
|
0.100 | Biomarker | disease | BEFREE | Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation. | 17189288 | 2007 |