Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Taken together, we demonstrated the differential expression of the heightened granzyme B and decreased TNF-<i>α</i> in NK and NKT-like cells in SLE patients. 31049024 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis. 31130331 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Genetic Versus Non-genetic Drivers of SLE: Implications of IRF5 Dysregulation in Both Roads Leading to SLE. 30645688 2019
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors. 28525378 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE We also found a significant association of serum TNF-α, interferon-α, IL-10 and IL-12 with SLE phenotypes. 26582004 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE Using a high-resolution melting curve analysis, we assessed the prevalence of TNF-α-308 G/A SNP in SLE patients (n = 262) and controls (n = 528) in a Polish population. 25661739 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Aberrant Low Expression of A20 in Tumor Necrosis Factor-α-stimulated SLE Monocytes Mediates Sustained NF-κB Inflammatory Response. 26107748 2015
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 AlteredExpression disease BEFREE RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE. 23349905 2013
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE SLE serum was identified as a trigger for IRF-5 nuclear accumulation; however, neither IFNα nor SLE immune complexes could induce nuclear localization. 21968701 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE We examined relative gene expression of tumour necrosis factor-alpha (TNF-α), interferon-γ (IFN-γ) and serum levels of interleukin-17 (IL-17) and IL-23 and their association with SLEDAI (SLE disease activity index) score and organ manifestations in pSLE. 22759859 2012
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 GeneticVariation disease BEFREE SLE-associated IRF5 haplotypes were correlated with the expression data and with the best cis-regulatory models. 21627826 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE Meta-analysis of TNF-α promoter -308A/G polymorphism and SLE susceptibility in Asian populations. 20333386 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE The mean serum TNF-alpha was significantly higher in the SLE patients compared to controls (P < .001). 22057071 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility. 20166876 2010
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 AlteredExpression disease BEFREE Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus. 20479222 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE The combined frequencies of IL-10 A/T/A haplotype and TNF-alpha G-G genotype were significantly increased in SLE patients. 20576226 2010
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE The significantly higher frequency of homozygote individuals for the risk haplotype among Mexican SLE patients could be the result of genetic admixture, and suggests the possibility that IRF5 could be involved in the more active disease and organ involvement known to occur among Mexican SLE patients. 17476532 2007
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Opposed independent effects and epistasis in the complex association of IRF5 to SLE. 17568788 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE Genetic susceptibility to SLE is associated with TNF-alpha gene polymorphism -863, but not -308 and -238, in Thai population. 18001298 2007
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
0.100 Biomarker disease BEFREE Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation. 17189288 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. 16418737 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE Stratification of patients suggested that DRB*1501 and TNF a11 frequencies were higher in SLE patients with renal disease and TNF a2 and b 3 frequencies in those without, although these differences did not reach statistical significance. 9543565 1998
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.090 Biomarker disease BEFREE IgM anti-phosphorylcholine antibodies associate with senescent and IL-17+ T cells in SLE patients with a pro-inflammatory lipid profile. 31302689 2020
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.090 Biomarker disease BEFREE Depression in SLE patients increased the release of pro-inflammatory cytokine (IL-6 and IL-17) that in turn generating more autoantibodies and showed strong recognition to 16α-OHE<sub>1</sub>-A. 30925322 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.090 Biomarker disease BEFREE SLE NETs were decorated with tissue factor (TF) and interleukin-17A (IL-17A), which promoted thrombin generation and the fibrotic potential of cultured skin fibroblasts. 30563869 2019