Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE Resultant N-terminal truncated IFN mimetics functioned intracellularly as antivirals as well as therapeutics against experimental allergic encephalomyelitis without the undesirable side effects that limit the therapeutic efficacy of IFNβ in treatment of multiple sclerosis. 23110939 2013
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE Furthermore, ferucarbotran treatment increased the number of CD3<sup>+</sup>, Iba-1<sup>+</sup>, IL-6<sup>+</sup>, Iba-1<sup>+</sup>TNF-α<sup>+</sup> and CD3<sup>+</sup>IFN-γ<sup>+</sup> cells in the spinal cord of EAE mice. 30863056 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE Purified IgG2a monoclonal anti-MOG antibody and mouse complement were stereotactically injected into the corpus callosum of wild-type and type I IFN receptor deficient mice (IFNAR1-KO) with and without pre-established experimental autoimmune encephalomyelitis (EAE). 28646890 2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE Adoptive transfer of in vitro DMF-treated myelin peptide-reactive IL-17A<sup>low</sup> IFN-γ<sup>low</sup> IL-4<sup>+</sup> CD4<sup>+</sup> T cells prior to immunization for EAE reduces the severity of encephalomyelitis. 30007005 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE IFN-β<sup>-/-</sup> DCs from mice immunized to develop EAE induce greater proliferation of MOG-transgenic CD4<sup>+</sup> T cells and promote interleukin-17 production by these T cells. 28646573 2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE The results showed that SHED infusion ameliorated EAE clinical score with reduced number of infiltrating IFN-γ<sup>+</sup>CD8<sup>+</sup>, IL-4<sup>+</sup>CD8<sup>+</sup>, IFN-γ<sup>+</sup>CD4<sup>+</sup> and IL-4<sup>+</sup>CD4<sup>+</sup> T cells into the central nervous system (CNS). 28666719 2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE In this work, we evaluated the sustained delivery of IFN-α1, either alone or fused to apolipoprotein A-1 by means of an adeno-associated viral (AAV) system in the mouse model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. 31209101 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE The generation of type 1 IFN can be minimized by using polar, nonionizable, amyloidogenic peptides, which are effective in both Th1 and Th17 polarized EAE. 25073790 2014
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE It can also amelioriate the development of experimental allergic encephalomyelitis (EAE) without the usual side effects of IFN therapy in mice autoimmunized with myelin basic protein. 10638702 1999
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE Ablation of the IFN-α/β receptor (IFNAR) in astrocytes using mGFAPcre IFNAR<sup>fl/fl</sup> mice resulted in severe encephalomyelitis and mortality, coincident with uncontrolled virus replication. 29491163 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.100 Biomarker disease BEFREE We found that treatment with CpG type A ODN (CpG-A), known to induce high amounts of IFN-<i>α</i> in pDCs, significantly reduced disease severity in EAE, relative to controls (12.63 ± 1.86 versus 23.49 ± 1.46, resp.; <i>p</i> = 0.001). 28356656 2017