Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE Recent studies in new EAE models, especially in transgenic ones, have in connection with new analytical techniques such as microarray assays provided a deeper insight into the pathogenic cellular and molecular mechanisms of EAE and potentially of MS. For example, it was possible to better delineate the role of soluble pro-inflammatory (tumor necrosis factor-α, interferon-γ and interleukins 1, 12 and 23), anti-inflammatory (transforming growth factor-β and interleukins 4, 10, 27 and 35) and neurotrophic factors (ciliary neurotrophic factor and brain-derived neurotrophic factor). 20558237 2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE In this study, we show that the expression of the neurotrophin receptor TrkB is induced on astrocytes in white matter lesions in multiple sclerosis (MS) patients and mice with experimental autoimmune encephalomyelitis (EAE). 22393127 2012
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE We engineered hematopoietic stem cells to produce BDNF to determine the feasibility and effectiveness of cell-based delivery of BDNF into the CNS in EAE.We review those studies here. 24601738 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE Our results suggest that the EAE-induced elevations in MeCP2E1 expression contribute to the repressed BDNF production in the spinal cord (SC). 28604632 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE The mMAPC-treated mice in comparison with the mMSC group exhibited a higher suppression of EAE (p < 0.05), and a higher fold expression of neuronal genes GAP43, NG2, PDGFR, Nestin, SMI 32, BDNF and NT 3 in spinal cord (p < 0.05), suggesting a better neuroprotective and regenerative potential of mMAPC than mMSC. 28621170 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE Kv3.3/Kv3.1 and activated BDNF receptors were upregulated in demyelinating axons in EAE and MS lesions. 29123469 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE In addition, hAMC treatment also promoted the production of neuron-repair factors (NGF, CNTF, and BDNF) in the CNS of EAE mice. 30035132 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 GeneticVariation disease BEFREE Like ARNT2, Npas4 levels also decline at the onset of EAE and are linked to decreases in Bdnf. 30231889 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE Roles of DNA 5-hydroxymethylcytosine (5hmC) in myelin repair were investigated in an experimental autoimmune encephalomyelitis (EAE) mouse model via its regulation on BDNF. 30426768 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE Of note, HE, not ME, swimming induced an increase of brain derived neurotrophic factor in the CNS of EAE. 30583216 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE It involved suppression of SGK1 but upregulation of BDNF, which then contributed to protection against EAE. 30820608 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE Theta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitis. 31556573 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE In summary, we have demonstrated that ADTC5 peptide modulates the BBB to permit non-invasive delivery of BDNF to exert its neuroregeneration activity in the brains of EAE mice. 31846344 2020