Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.270 | Biomarker | disease | BEFREE | IFN-β is widely used in the treatment of MS and is found to decrease IL-17 and OPN production in MS patients and EAE mice. | 29127843 | 2018 | ||||
|
0.270 | Biomarker | disease | BEFREE | Vaccination significantly induced antibodies against OPN during EAE, decreased disease severity, and the protective effect was correlated with decreased T cell secretion of interleukin 17 and interferon-γ <i>ex vivo</i>. | 28386258 | 2017 | ||||
|
0.270 | Biomarker | disease | BEFREE | The data showed that in EAE rats OPN mRNA and protein levels increased concurrently with the transcription of MTs and that within the spinal cord (SC) lysates EAE-afflicted rats had a higher content of OPN fragments of low molecular weight than untreated and CFA-treated rats. | 28344072 | 2017 | ||||
|
0.270 | Biomarker | disease | BEFREE | Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo. | 27478856 | 2016 | ||||
|
0.270 | Biomarker | disease | BEFREE | Anti-Opn was also effective in reducing clinical severity of EAE when given after the appearance of clinical symptoms. | 19017937 | 2008 | ||||
|
0.270 | AlteredExpression | disease | BEFREE | Osteopontin transcription is increased in the central nervous system of patients with multiple sclerosis and rats with experimental allergic encephalomyelitis; where expression correlates with disease severity. | 12928913 | 2003 | ||||
|
0.270 | Biomarker | disease | BEFREE | Osteopontin-deficient mice were resistant to progressive EAE and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma than in OPN+/+ mice. | 11721059 | 2001 | ||||
|
0.270 | Biomarker | disease | RGD | The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. | 11721059 | 2001 |