Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Osteopontin-deficient mice were resistant to progressive EAE and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma than in OPN+/+ mice. 11721059 2001
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease RGD The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. 11721059 2001
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 AlteredExpression disease BEFREE Osteopontin transcription is increased in the central nervous system of patients with multiple sclerosis and rats with experimental allergic encephalomyelitis; where expression correlates with disease severity. 12928913 2003
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Anti-Opn was also effective in reducing clinical severity of EAE when given after the appearance of clinical symptoms. 19017937 2008
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo. 27478856 2016
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Vaccination significantly induced antibodies against OPN during EAE, decreased disease severity, and the protective effect was correlated with decreased T cell secretion of interleukin 17 and interferon-γ <i>ex vivo</i>. 28386258 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE The data showed that in EAE rats OPN mRNA and protein levels increased concurrently with the transcription of MTs and that within the spinal cord (SC) lysates EAE-afflicted rats had a higher content of OPN fragments of low molecular weight than untreated and CFA-treated rats. 28344072 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE IFN-β is widely used in the treatment of MS and is found to decrease IL-17 and OPN production in MS patients and EAE mice. 29127843 2018