Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 Biomarker disease BEFREE IL-27 signaling in Tregs was necessary, as transferring Tregs deficient in IL-27Rα or Lag3, a downstream molecule induced by IL-27, was unable to protect mice from experimental autoimmune encephalomyelitis. 30700587 2019
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 Biomarker disease BEFREE Adoptive transfer of AAV-IL-27-expanded CD11b<sup>+</sup>Gr-1<sup>+</sup> cells enhanced EAE development. 29740452 2018
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 Biomarker disease BEFREE Our data reveal a new cellular regulatory mechanism of IL-27 that targets DC-mediated immune responses in autoimmune diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). 30483251 2018
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 Biomarker disease BEFREE IL-27 exerts protective effects in autoimmune diseases like experimental autoimmune encephalomyelitis; however, its role in the pathogenesis of osteoporosis remains to be determined. 28130449 2017
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 Biomarker disease BEFREE We immunized wild-type (WT) and IL-27 receptor (WSX-1) knockout mice with MOG<sub>35-55</sub> for induction of experimental autoimmune encephalomyelitis and intravenously (i.v.) injected them with MOG<sub>35-55</sub> after onset of disease to induce i.v. tolerance. i.v. administration of MOG<sub>35-55</sub> reduced disease severity in WT mice, but was ineffective in <i>Wsx</i><sup>-/-</sup> mice. 29163476 2017
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 Biomarker disease BEFREE As IL-27 alleviates experimental autoimmune encephalomyelitis, we hypothesized that IL-27 suppresses GM-CSF expression by T cells. 22837488 2012
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 Biomarker disease BEFREE Recently, IL-27 was found to play a role in suppressing experimental autoimmune uveitis and experimental autoimmune encephalomyelitis, two animal models that share essential pathological features of human uveitis and multiple sclerosis, respectively. 21294722 2011
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 AlteredExpression disease BEFREE Complementary in vivo studies in a mouse model showed that treatment with IFN-β enhanced expression of IL-27, and reduced IL-17 in the CNS and periphery and attenuated the clinical signs of experimental autoimmune encephalomyelitis (EAE). 21420486 2011
Entrez Id: 246778
Gene Symbol: IL27
IL27
0.090 AlteredExpression disease BEFREE By generating mice deficient for the p28 subunit of IL-27, we showed that IL-27 regulated the severity of delayed-type hypersensitivity response and EAE through its effects on Th17 cells. 19380822 2009