Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression disease BEFREE Collectively, these findings indicate that decreased miR-497 expression is responsible for IL-17-triggered high HIF-1α expression and consequent IL-1β and IL-6 production by astrocytes in EAE mice.Cellular & Molecular Immunology advance online publication, 1 May 2017; doi:10.1038/cmi.2017.12. 28458392 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Physical exercise inhibited the production of inflammatory cytokines, such as IFN-γ, IL-17 and IL-1β in the spinal cord after EAE induction, as well as spleen cells obtained from ST group showed a significant upregulation of regulatory T cell markers, such as CD25 and IL-10 levels, and blocked IL-6, MCP-1 and TNF-α production, mainly, during acute and chronic phase of EAE. 27447807 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE The role of IL-6 in regulating progressive CNS autoimmunity was assessed by treating GFAPγR1Δ mice with anti-IL-6 neutralizing antibody during chronic EAE. 25896970 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE In this research, an IL6-associated miRNA, miR26a, was identified, and its normally downregulated expression was shown to be highly correlated with disease severity in patients suffering from MS as well as in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE; a well-established animal model of human MS). 25362566 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE EAE mice with hMSC treatment on day 3 and day 12 had: (1) lower serum levels of IL-6, TNF-α (p < 0.0005), and IL-17 (p < 0.005 for day 3, p < 0.0005 for day 12); (2) reduced splenic cell production and secretion of IL-6, TNF-α (p < 0.05), and IL-17 (p < 0.05), and increased splenic production of IL-10; (3) reduced splenic Th17 cells (p < 0.05 for day 3, p < 0.005 for day 12), and (4) increased CD1d(high)CD5(+) regulatory B cells (p < 0.005) compared to EAE mice without hMSC treatment. 23899693 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE The severe EAE developed by Hx(-/-) mice could be ascribed to an enhanced expansion of Th17 cells accounting for both a higher disposition of naive T cells to differentiate toward the Th17 lineage and a higher production of Th17 differentiating cytokines IL-6 and IL-23 by APCs. 24154625 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE More importantly, B(GMME3) inhibit the reactivation of encephalomyelitis (EAE)-derived or TGFβ/IL6 differentiated Th17 cells by altering their polarization toward a Th1 or Th2 phenotype. 22760541 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Taking these data together, we conclude that IL-6 secretion is a major mechanism of B cell-driven pathogenesis in T cell-mediated autoimmune disease such as EAE and MS. 22547654 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression disease BEFREE The suppression of EAE was accompanied by reduced mRNA levels of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 in the spinal cord cellular infiltrates and microglia from ghrelin-treated mice at the peak of disease, suggesting the role of ghrelin as an antiinflammatory hormone. 19620309 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression disease BEFREE Although we demonstrate that IL-17F expression is restricted to CD4(+) T cells during experimental autoimmune encephalomyelitis, IL-17F-Cre(EYFP) CD8 T cells robustly expressed IL-17F in response to TGF-beta, IL-6, and IL-23. 19155467 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Based on a number of adjuvant-induced experimental models, IL-6 is critical to the development of autoimmune diseases including experimental autoimmune encephalomyelitis, adjuvant-induced arthritis, and experimental autoimmune myocarditis. 19758168 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Interleukin-6 (IL-6) plays an important role in the regulation of the inflammatory response in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). 12736743 2003
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE IL-6 is critically involved in experimentally induced autoimmune disease, such as antigen-induced arthritis (AIA), and experimental allergic encephalomyelitis. 12220549 2003
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Interleukin-6 (IL-6) has been implicated in the etiology of experimental autoimmune encephalomyelitis (EAE) in transgenic animals and contributes to neuropathology in humans. 11574109 2001
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Interleukin-6 (IL-6) plays an important role in the regulation of the inflammatory response in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). 11072134 2000
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE These results indicate that IL-6 may play a crucial role in the induction phase of EAE. 9645618 1998
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker disease BEFREE Adoptive transfer of Tcell lines from IL-6+/+ mice induced EAE in the mice with the intact IL-6 gene but less in the IL-6-deficient mice, indicating that the resistant phenotype cannot be explained solely by lack of encephalitogenic Tcells. 9603480 1998