Introduction of miR-223-3p in vivo in mouse retinal ganglion cells protects their axons from degeneration in experimental autoimmune encephalomyelitis.
MiR-223 knock out (miR-223<sup>-/-</sup>) mice developed less severe EAE with increased MDSC numbers in the spleen and spinal cord compared to littermate controls.
Expression of the genes associated with dendritic cell (DC) activation (CD86 and MHC II) and Th1 and Th17 differentiation [interleukin-12 (IL-12) and IL-23, respectively] was significantly decreased in the spleens of miR223(-/-) mice bearing EAE.