Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 AlteredExpression disease BEFREE Furthermore, there was a reduction in the levels of inflammatory cytokines including IL-17 (<i>P </i>= 0.009) and IL-23 (<i>P </i>= 0.012) and confirmed increased serum antioxidant levels in <i>A. dracunculus</i> treated EAE mice (<i>P </i>= 0.008).<b>Conclusions:</b> These observations indicate that <i>A. dracunculus</i> extracts could reduce inflammatory cytokines and attenuate certain signs of EAE, suggesting the potential of a useful adjuvant therapy for MS. 31665978 2019
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 AlteredExpression disease BEFREE <b>Results:</b> The expression of IL-17, IL-23 P19, IL-23 P40, CCL20, CCL22 and CCR4 in spinal cord and serum IL-17 and IL-23 levels in PBS-administrated EAE mice were significantly increased compared with healthy group. 29447086 2019
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE We previously designed and prepared rhIL23R-CHR protein to antagonize endogenous IL-23, showing effectiveness in the treatment of experimental autoimmune encephalomyelitis (EAE) in mice. 28395256 2017
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Knockout of P2Y<sub>12</sub> aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells. 27939246 2017
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Expression of the genes associated with dendritic cell (DC) activation (CD86 and MHC II) and Th1 and Th17 differentiation [interleukin-12 (IL-12) and IL-23, respectively] was significantly decreased in the spleens of miR223(-/-) mice bearing EAE. 27083389 2016
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Among them, IL-23 is essential for the generation of stable and encephalitogenic Th17 cells and for the development of EAE. 26223651 2015
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Here we identify a temporally regulated IL-23-dependent switch from CCR6 to CCR2 usage by developing Th17 cells that is critical for pathogenic Th17 cell-driven inflammation in experimental autoimmune encephalomyelitis (EAE). 26511769 2015
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 AlteredExpression disease BEFREE In addition to the in vitro inhibition of human Th17 cells in a dose-dependent manner, the antagonizing effect of hIL23R-CHR was confirmed by reduced levels of IL-23 in both blood and brain of EAE mice and STAT3 phosphorylation in vivo. 25263529 2014
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Therefore, this study was designed to evaluate the therapeutic efficacy of bone marrow-derived DCs (BMDCs) transduced with lentiviral vectors to permanently expressed shRNA specific for CD40 (CD40LV-DCs) and/or p19 subunit of interleukin (IL)-23 (p19LV-DCs) mRNAs in experimental autoimmune encephalomyelitis (EAE). 24387596 2014
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE The severe EAE developed by Hx(-/-) mice could be ascribed to an enhanced expansion of Th17 cells accounting for both a higher disposition of naive T cells to differentiate toward the Th17 lineage and a higher production of Th17 differentiating cytokines IL-6 and IL-23 by APCs. 24154625 2013
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Pathogenic IL-23-dependent TH17 cells have been shown to be critical for the development of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, and genetic risk factors associated with multiple sclerosis are related to the IL-23-TH17 pathway. 23467095 2013
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE There are also examples of mechanisms that have worked in EAE but have failed in the clinic, such as the TNFα antagonists and anti-p40 (a subunit of IL-12 and IL-23). 20380590 2010
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 AlteredExpression disease BEFREE Although we demonstrate that IL-17F expression is restricted to CD4(+) T cells during experimental autoimmune encephalomyelitis, IL-17F-Cre(EYFP) CD8 T cells robustly expressed IL-17F in response to TGF-beta, IL-6, and IL-23. 19155467 2009
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Combinations of interleukin (IL)-1beta, IL-6, and IL-23 with transforming growth factor beta were used to differentiate myelin-specific T cell receptor transgenic T cells into Th17 cells, none of which could induce EAE, whereas Th1 cells consistently transferred disease. 19546248 2009
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE However, evidence from recent studies strongly supports the critical role of IL-12-related proinflammatory cytokine IL-23, but not IL-12, in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of this disease. 17003070 2007
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE Mice lacking IL-23 (p19-/-) do not develop experimental autoimmune encephalomyelitis (EAE) or collagen-induced arthritis (CIA), while knockout mice for the Th1 cytokine IL-12 (p35-/-) strongly develop both autoimmune diseases. 17289553 2007
Entrez Id: 51561
Gene Symbol: IL23A
IL23A
0.100 Biomarker disease BEFREE In a recent study, it has been demonstrated that IL-23 rather than IL-12 is critical for modulating the character of the developing immune response towards a proinflammatory response and leading to EAE. 16386239 2005