|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, we systematically analyzed changes of the TCRβ repertoire driven by EAE and pregnancy using TCR sequencing.
|
31444265 |
2019 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, when co-transferred with myelin-specific 2D2 TCR-transgenic naive T cells, unrelated OT-II TCR-transgenic memory-like T<sub>H</sub>17 cells infiltrate the spinal cord and produce IL-17A, interferon (IFN)-γ, and GM-CSF, increasing the susceptibility of the recipients to experimental autoimmune encephalomyelitis in an IL-1 receptor-dependent manner.
|
30755603 |
2019 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adoptive transfer of blastogenic CD25<sup>high</sup> FOXP3<sup>+</sup> Tregs from MOG35-55-specific 2D2 TCR transgenic mice suppressed experimental autoimmune encephalomyelitis in pretreatment and therapeutic protocols.
|
29312311 |
2017 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
In TCR transgenic mice, the "EAE-susceptibility-associated" epitope was "ignored" by specific CD4 T cells, whereas the "resistance-associated" epitope induced clonal deletion and T<sub>reg</sub> induction in the thymus.
|
29170668 |
2017 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated the ability of a newly designed monomeric recombinant TCR ligand (RTL342M) containing HLA-DR2 peptide-binding domains covalently linked to MOG-35-55 peptide to prevent and treat both the initial episode and subsequent relapses of experimental autoimmune encephalomyelitis (EAE) in HLA-DR2 transgenic mice.
|
17257899 |
2007 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice transgenic for this human TCR and DRA and DRB1*1501 chains develop spontaneous experimental autoimmune encephalomyelitis.
|
15265898 |
2004 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice.
|
12816990 |
2003 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transient genetic delivery of the TCR Vbeta8.2 chain protected mice from Ag-induced experimental autoimmune encephalomyelitis.
|
12517939 |
2003 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Major histocompatibility complex (MHC) class II and T-cell receptor (TCR) gene polymorphisms play important roles in rodent susceptibility to EAE and were analyzed to determine if the same was true in humans with SAE.
|
10319881 |
1999 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diagnosis and assessment of preclinical and clinical autoimmune encephalomyelitis using peripheral blood lymphocyte TCR.
|
9754562 |
1998 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
The extensive parallels between human T cells specific for V beta 5.2 and V beta 6.1 CDR2 peptides and rat T cells specific for V beta 8.2 CDR2 peptide that are highly protective against experimental encephalomyelitis strengthen the rationale for the therapeutic use of TCR peptides in human autoimmunity.
|
7510747 |
1994 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunization with disease-associated TCR V region peptides is an effective treatment for experimental autoimmune encephalomyelitis.
|
7510746 |
1994 |
|
TRBV20OR9-2
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to establish whether such T cell responses are likely to be antigen-specific particularly with regard to myelin basic protein (MBP), we analysed T-cell receptor (TCR) gene rearrangements directly from MS brain plaques, using the polymerase chain reaction on reverse transcribed messenger RNA, and compared these with TCR of previously described MBP-specific T cell clones from MS and the rat model experimental allergic encephalomyelitis.
|
7680433 |
1993 |
|
TRBV20OR9-2
|
0.100 |
Biomarker
|
disease |
BEFREE |
Synthetic peptides corresponding to germline TCR V beta 8.2 sequences overexpressed by Lewis rat encephalitogenic T cells are effective in the prevention and treatment of autoimmune encephalomyelitis (EAE).
|
7686833 |
1993 |