Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE IFN-β is widely used in the treatment of MS and is found to decrease IL-17 and OPN production in MS patients and EAE mice. 29127843 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Vaccination significantly induced antibodies against OPN during EAE, decreased disease severity, and the protective effect was correlated with decreased T cell secretion of interleukin 17 and interferon-γ <i>ex vivo</i>. 28386258 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE The data showed that in EAE rats OPN mRNA and protein levels increased concurrently with the transcription of MTs and that within the spinal cord (SC) lysates EAE-afflicted rats had a higher content of OPN fragments of low molecular weight than untreated and CFA-treated rats. 28344072 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo. 27478856 2016
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Anti-Opn was also effective in reducing clinical severity of EAE when given after the appearance of clinical symptoms. 19017937 2008
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 AlteredExpression disease BEFREE Osteopontin transcription is increased in the central nervous system of patients with multiple sclerosis and rats with experimental allergic encephalomyelitis; where expression correlates with disease severity. 12928913 2003
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease BEFREE Osteopontin-deficient mice were resistant to progressive EAE and had frequent remissions, and myelin-reactive T cells in OPN-/- mice produced more interleukin 10 and less interferon-gamma than in OPN+/+ mice. 11721059 2001
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.270 Biomarker disease RGD The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. 11721059 2001
Entrez Id: 4340
Gene Symbol: MOG
MOG
0.100 GeneticVariation disease BEFREE For this aim, mice were immunized with myelin oligodendrocyte glycoprotein 35-55 (MOG35-55), followed by pertussis toxin to induce paralysis in EAE mice. 31830622 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 Biomarker disease BEFREE Besides, proinflammatory cytokines such as, IFN-γ, TNF-α, IL-6, and IL-17 were significantly diminished in the serum and spinal cord of EAE mice receiving HIV-1 Tat clade B and C. Conversely, anti-inflammatory cytokines, including IL-10 and IL-4 were elevated in the serum and spinal cord of EAE mice receiving HIV Tat clade B and C when compared with the control group. 31830622 2020
Entrez Id: 4397
Gene Symbol: MS
MS
0.100 Biomarker disease BEFREE Herein we demonstrate that two C-type lectin receptors (CLRs), Mcl and Mincle, play an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of Multiple Sclerosis (MS). 31725411 2020
Entrez Id: 4340
Gene Symbol: MOG
MOG
0.100 Biomarker disease BEFREE We used myelin oligodendrocyte glycoprotein (MOG) to induce experimental autoimmune encephalomyelitis (EAE), a widely-accepted animal model of MS, in C57BL/6 mice. 31589901 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression disease BEFREE Our results revealed that the serum concentrations of T-helper 1 (Th1) and Th17 cytokines, interleukin (IL)-6, IL-1β, IL-1α and prostaglandin E2 in EAE mice were significantly higher than controls. 31709666 2020
Entrez Id: 4340
Gene Symbol: MOG
MOG
0.100 GeneticVariation disease BEFREE We sought to determine the role and mechanism of action of miRNA-125a-5p and VDRs in a model of MS, mice with experimental autoimmune encephalomyelitis (EAE), which was induced by myelin oligodendrocyte glycoprotein 35-55 peptides. 31428926 2020
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE The increased amounts of the i-20S-specific subunit β5i and PA28α/β in EAE correlate with the levels of interferon-γ and its downstream effectors p-signal transducer and activator of transcription 1 and interferon regulatory factor-1, but not with those of nuclear factor kappa-light-chain-enhancer of activated B cells. 31709534 2020
Entrez Id: 4155
Gene Symbol: MBP
MBP
0.100 Biomarker disease BEFREE We previously showed that an MHC class I-restricted epitope of myelin basic protein (MBP) is presented in the CNS during CD4+ T cell-initiated EAE. 31573979 2020
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1
0.100 Biomarker disease BEFREE Effective IFN-β therapy in B cell-independent EAE was associated with reduced inflammatory T cells in the CNS and skewed splenic B cells towards an immature population and away from a germinal center population. 31715458 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 AlteredExpression disease BEFREE In summary, we have demonstrated that ADTC5 peptide modulates the BBB to permit non-invasive delivery of BDNF to exert its neuroregeneration activity in the brains of EAE mice. 31846344 2020
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 Biomarker disease BEFREE Besides, proinflammatory cytokines such as, IFN-γ, TNF-α, IL-6, and IL-17 were significantly diminished in the serum and spinal cord of EAE mice receiving HIV-1 Tat clade B and C. Conversely, anti-inflammatory cytokines, including IL-10 and IL-4 were elevated in the serum and spinal cord of EAE mice receiving HIV Tat clade B and C when compared with the control group. 31830622 2020
Entrez Id: 4340
Gene Symbol: MOG
MOG
0.100 Biomarker disease BEFREE Upregulation of periostin in MOG-induced experimental autoimmune encephalomyelitis in mice. 31639420 2020
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Here, we demonstrated that an NFAT inhibitory peptide, VIVIT conjugated to dNP2 (dNP2-VIVIT), a blood-brain barrier-permeable peptide, ameliorated experimental autoimmune encephalomyelitis (EAE) by inhibiting Th1 and Th17 cells, but not regulatory T (T<sub>reg</sub>) cells. dNP2-VIVIT negatively regulated spinal cord-infiltrating interleukin-17A (IL-17A) and interferon (IFN)-γ-producing CD4<sup>+</sup> T cells without affecting the number of Foxp3<sup>+</sup> CD4<sup>+</sup> T<sub>reg</sub> cells, whereas dNP2-VEET or 11R-VIVIT could not significantly inhibit EAE. 31737742 2020
Entrez Id: 4340
Gene Symbol: MOG
MOG
0.100 Biomarker disease BEFREE The goal of the present study was to determine whether MYMD-1 would produce similar beneficial effects in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin oligodendrocyte glycoprotein. 31778849 2020
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Besides, proinflammatory cytokines such as, IFN-γ, TNF-α, IL-6, and IL-17 were significantly diminished in the serum and spinal cord of EAE mice receiving HIV-1 Tat clade B and C. Conversely, anti-inflammatory cytokines, including IL-10 and IL-4 were elevated in the serum and spinal cord of EAE mice receiving HIV Tat clade B and C when compared with the control group. 31830622 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.100 Biomarker disease BEFREE Of note, HE, not ME, swimming induced an increase of brain derived neurotrophic factor in the CNS of EAE. 30583216 2019
Entrez Id: 4340
Gene Symbol: MOG
MOG
0.100 Biomarker disease BEFREE We implemented a preclinical scheme to foster immune tolerance to myelin oligodendrocyte glycoprotein (MOG), in a cynomolgus-macaque model of experimental autoimmune encephalomyelitis (EAE), in which administration of recombinant human MOG (rhMOG) elicits brain inflammation mediated by MOG-autoreactive CD4<sup>+</sup> lymphocytes and anti-MOG IgG. 31492559 2019