While no significant differences were observed for CD58 and CD106, a significantly reduced expression of CD54 in the secretory endometrial cells of women with endometriosis was observed (-75% with respect to apparently healthy controls).
When compared with controls, women with stage III and IV endometriosis had higher serum concentrations of soluble VCAM-1, lower serum concentration of soluble ICAM-1, and no difference in serum concentration of soluble E-selectin.
Our results suggest that the IL-6 -634C/G and ICAM-1 469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population.
Our results suggest that the IL-6 -634C/G and ICAM-1469K/E polymorphisms synergistically affect the susceptibility for endometriosis in the Japanese population.
The combination of TNF and MMP9 increased the sICAM1 concentration 14-fold in the endometriosis cell media, whereas GM6001 inhibited the stimulatory effect of TNF in both cell cultures.
The K469E and G241R polymorphisms in the ICAM-1 gene and the C-634G polymorphism in the IL-6 gene may not be genetic factors related to susceptibility to advanced-stage endometriosis in the Korean population.
Our results suggest that ICAM-1 polymorphism in codon 241 is associated with the development of endometriosis susceptibility in the population of northern Iran.
Independent data for the late stages of endometriosis suggest protection of the ICAM-1K469E polymorphism among the Asians (OR 0.91-0.95, p = 0.35-0.71).
The mRNA levels of VCAM-1, ICAM-1 and epithelial cell adhesion molecule (EpCAM) were measured using quantitative real-time PCR, and serum protein levels of soluble VCAM-1 (sVCAM-1), ICAM-1 (sICAM-1) and EpCAM (sEpCAM) were measured using ELISA and correlated with endometriosis status.