Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Dienogest, a specific progesterone receptor agonist, is used in the treatment of endometriosis. 31814016 2020
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE Patients with endometriosis presented lower levels of progesterone receptor type B expression. 30638056 2019
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 GeneticVariation disease BEFREE The <i>PGR-A</i> gene showed 0% of DNA methylation (unmethylated) in both control and endometriosis groups. 30782101 2019
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE An immunohistochemistry study demonstrated that the estrogen receptor (ER) and progesterone receptor (PR) were positive in the endometriosis part but negative in the cancer part, while the human EGF receptor (HER) 2 was negative or very weak in the benign part and positive in the malignant part in all three cases. 29998468 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Efficacy, safety and recurrence of new progestins and selective progesterone receptor modulator for the treatment of endometriosis: a comparison study in mice. 29615065 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE Therefore, our study demonstrated that miR-194-3p contributes to progesterone resistance in endometriosis, which hinders fertility by repressing the levels of PR and decidualization in the EuE. 29762665 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE The progesterone receptor (PR) plays an important role in various physiological systems, including female reproduction and the central nervous system, and PR antagonists are thought to be effective not only as contraceptive agents and abortifacients but also in the treatment of various diseases, including hormone-dependent cancers and endometriosis. 30034593 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE The results suggested that miRNAs, ER, and PR could play important roles in the embryo implantation period of rats with endometriosis. 30203794 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Ascertainment of PR status may allow for a novel, targeted, precision-based approach to treating endometriosis. 30357380 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Heterogeneity of estrogen receptor α and progesterone receptor distribution in lesions of deep infiltrating endometriosis of untreated women or during exposure to various hormonal treatments. 29383962 2018
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis. 28891417 2017
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE On pathological examination, she was found to have a focus of endometriosis in the para-tubal soft tissue showing a morphology similar to progesterone receptor modulator associated endometrial changes (PAEC). 27914766 2017
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of endometriosis. 28742263 2017
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE Immunohistochemistry was performed to compare PR-B expression between eutopic and ectopic endometrial tissues from women with and without advanced-stage endometriosis. 27593876 2016
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE We showed that the miR-196a level is associated with reduced expression of PGR isoforms through MEK/ERK, suggesting that miR-196a and MEK/ERK are both potential biomarkers of endometriosis. 27619769 2016
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Defective CpG methylation affecting several genes that encode key transcription factors such as GATA6, steroidogenic factor-1, and estrogen receptor-β in endometriosis gives rise to overproduction of local estrogen and prostaglandins and suppression of progesterone receptor. 26036904 2015
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE Dienogest (DNG), a selective progesterone receptor agonist, is widely used to treat endometriosis and efficiently relieves the symptoms. 25767055 2015
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE Decreased expression of mucin-1 in endometriosis endometrium correlated with progesterone receptor B involved in infertility. 25155819 2015
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE In the present study, we investigated the pharmacological effects of DNG through these PR isoforms on the expression of CYP19A1 which encodes aromatase and inflammatory and neuroangiogenesis factors associated with the pain and progression of endometriosis. 25533385 2015
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 Biomarker disease BEFREE These results suggest that the CRISPLD2 is a target of the progesterone receptor and may play an important role in pathogenesis of endometriosis. 24955763 2014
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 GeneticVariation disease BEFREE The present study demonstrated that epigenetic changes occur in both promoter regions of the PGR gene in intestinal endometriosis. 24481237 2014
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 GeneticVariation disease BEFREE Association of the progesterone receptor gene polymorphism (PROGINS) with endometriosis: a meta-analysis. 24943061 2014
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis. 24064688 2013
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 GeneticVariation disease BEFREE Endometriosis is often treated with progestins, which act as progesterone receptor agonists, although their exact mechanisms of action are not completely understood. 23183084 2013
Entrez Id: 5241
Gene Symbol: PGR
PGR
0.600 AlteredExpression disease BEFREE Eutopic endometrium from women with endometriosis had reduced expression of KLF9 mRNA together with those of PGR-B, WNT4, WNT2, and DKK1. 22259059 2012