| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Hsa-miR-451 in FF was downregulated in endometriosis patients relative to control subjects (P < 0.01). | 31744497 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We observed lower miR-451 levels in eutopic endometrial tissues from patients with EMs than in control tissues, and this difference was not related to the American Society for Reproductive Medicine stage. | 31531311 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Using an experimental mouse model of endometriosis in which ectopic endometriotic lesions were deficient for both of these miRNAs revealed that miR-451a, but not miR-144-3p may be derived from exogenous sources such as the circulation/erythrocytes. | 31217548 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Treatment with miR-451a inhibitor resulted in reduced endometriosis lesion size (30 vs 13 mm<sup>3</sup>). | 31354069 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | The objective of the current study was to examine the relationship between lesion and serum content of miR-451a and to determine the utility of serum miR-451a in distinguishing between women with and without visible signs of endometriosis. | 27920341 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Timed endometrial biopsies from women with and without endometriosis were also used to validate the expression of miR-451. | 26370665 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The exact pattern of expression and role of miR451 in endometriosis is currently unknown. | 25637622 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Collectively, these results suggest that the reduced miR-451 eutopic endometrial expression does not enhance initial establishment of these fragments when displaced into the peritoneal cavity, that loss of eutopic endometrial miR-451 expression is associated with altered expression of fibrinogen alpha chain mRNA and protein, and that RGD cyclic peptide antagonists inhibit establishment of endometriosis development in an experimental mouse model suggesting that this approach may prove useful in the prevention of endometriosis establishment and survival. | 24937656 | 2014 |