Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 AlteredExpression group BEFREE Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication. 31829496 2020
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 GeneticVariation group BEFREE Here, we investigated the role of acyl-coenzyme A binding domain containing 3 (ACBD3) in PI4KB recruitment upon enterovirus replication using ACBD3 knockout (ACBD3<sup>KO</sup>) cells. 30755512 2019
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 Biomarker group BEFREE This work supports a two-step resistance model of enterovirus to PI4KB/OSBP inhibitors involving unique recessive epistasis of 3A and 2B and offers insights into a potential evolutionary pathway of enterovirus toward independence from the PI4KB/OSBP pathway. 30919621 2019
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 Biomarker group BEFREE These findings suggest that interaction of PI4KB with these host proteins is not essential for EV replication once PI4KB has been expressed and that PI4KB is functionally independent from these host proteins regarding EV replication. 31166044 2019
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 Biomarker group BEFREE These results reveal a mechanism of enterovirus replication that involves a selective strategy for recruitment of PI4KB to the RNA replication sites.<b>IMPORTANCE</b> Enterovirus 71, like other human enteroviruses, replicates its genome within host cells, where viral proteins efficiently utilize cellular machineries. 28701404 2017
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 Biomarker group BEFREE Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosphate (PI4P), is only partially understood. 29045829 2017
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 GeneticVariation group BEFREE Enterovirus mutants resistant to inhibitors of PI4KB and OSBP were previously isolated, which demonstrated a role of single substitutions in the non-structural 3A protein in conferring resistance. 29024767 2017
Entrez Id: 5298
Gene Symbol: PI4KB
PI4KB
0.080 Biomarker group BEFREE To date, ARF1, ACBD3, BIG1/BIG2, GBF1, RTN3, and PI4KB have been identified as host factors of enterovirus (EV), including PV, involved in membrane traffic. 22379090 2012