Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE These effects are caused by in utero exposure to maternal IL-5 and resulting fetal eosinophilia. 31821769 2020
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Intravenous reslizumab, a monoclonal IL-5 antibody, is approved for treating severe asthma with eosinophilia. 31404668 2020
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Notably, jejunum eosinophilia in IL-5-deficient-Fabpi-IL-18 mice is significantly induced compared with wild-type mice, which indicates the direct role of induced IL-18 in the tissue accumulation of eosinophils and mast cells. 30779114 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3<sup>+</sup> Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis. 30930900 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE The role of eosinophilia in atopic diseases, including asthma, is well established, as is the well-known role of IL-5 as a major eosinophilopoeitin and chemoattractant. 31415658 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Eosinophilic COPD may represent an overlap with asthma but the mechanism of eosinophilia is uncertain as, although an increase in sputum IL-5 has been detected, anti-IL-5 therapies are not effective in preventing exacerbations. 30834543 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE After epithelial barrier disruption, intranasal OVA application induced higher OVA-specific IgG1 and total IgE in serum, and increased eosinophilia and interleukin-5 in bronchoalveolar lavage (BAL) compared to sham-OVA mice. 31769882 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 AlteredExpression disease BEFREE In addition to evidence of mast cell activation, mucosa from patients with EoE have increased levels of interleukin 5; supporting eosinophilia; and upregulation of gene expression of eotaxin-3, a chemokine important in eosinophil migration. 31690395 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Finally, treatment of humanized mice with anti-Siglec antibody led to robust depletion of IL-5-induced eosinophilia in vivo. 30543818 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 AlteredExpression disease BEFREE In addition, eosinophils increased in the bronchoalveolar lavage fluids, alone with the elevated levels of Th-2 type cytokines [interleukin (IL)-4, IL-5 and IL-13], eotaxin, and adhesion molecules. 30589094 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 AlteredExpression disease BEFREE Strong granzyme B<sup>+</sup>, interferon (IFN)-γ<sup>+</sup> CD8<sup>+</sup> cytotoxic T cell and circulating regulatory T (T<sub>reg</sub>) cell responses were noted during allograft rejection, along with significant eosinophilia and elevated serum IL-5 and eotaxin levels. 31624262 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 AlteredExpression disease BEFREE This patient also had marked eosinophilia and high levels of thymus and activation-regulated chemokine and interleukin-5 in the serum. 29573413 2019
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Bone marrow type 2 innate lymphoid cells: a local source of interleukin-5 in interleukin-33-driven eosinophilia. 28921511 2018
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE In both models, targeted deletion of RORα in mouse T<sub>regs</sub> led to exaggerated eosinophilia driven by interleukin-5 (IL-5) production by ILC2s and T<sub>H</sub>2 cells. 29500225 2018
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Upstream Regulator Analysis revealed that not only T-helper 2 (Th2) and the eosinophilia-related molecules (interleukin 4 [IL4], IL5, and colony stimulating factor 2 [CSF2]) reported so far, but also cell cycle regulators (cyclin dependent kinase inhibitor 1A [CDKNA1] and cyclin D1 [CCND1]) and a tissue fibrosis-related molecule (transforming growth factor β [TGFβ]) were identified in ECRSwNP. 29337425 2018
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE The most important cytokine involved in the induction, maintenance, and amplification of airway eosinophilia in asthma is interleukin-5 (IL-5), released by both T helper 2 (Th2) lymphocytes and group 2 innate lymphoid cells (ILC2). 29862274 2018
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Similarly, ST2 + IL-5+ HPC numbers were increased in the sputum of COPD patients with airway eosinophilia (p < 0.001). 29859068 2018
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 AlteredExpression disease BEFREE A type 2 immune response was associated with exposure, with increased interleukin-4 (IL-4) production, IL-5 transcription, and eosinophilia. 28993458 2018
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE These data are consistent with the hypothesis that the eosinophilia in FE is secondary to dysregulation of IL-5 production in PBMC (and their component subsets). 28226398 2017
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 GeneticVariation disease BEFREE We investigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of the interleukin-5 receptor that significantly reduces the incidence of asthma exacerbations, was also effective as an oral glucocorticoid-sparing therapy in patients relying on oral glucocorticoids to manage severe asthma associated with eosinophilia. 28530840 2017
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Conspicuous eosinophilia in early-onset FPIES is suggested to be caused by abnormally high IL-5 production. 27624222 2017
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Based on the data presented, I propose omalizumab for patients with an allergic phenotype regardless of their peripheral eosinophilic count, and anti-IL-5 as an alternative in allergic patients with blood eosinophilia in which omalizumab has failed; anti-IL5 for patients with an eosinophilic phenotype and omalizumab as an alternative in patients in whom anti-IL5 fails and IgE ≥30 IU/mL (compassionate use). 28948572 2017
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Such a mechanism may explain the protective effect of parasite infection in patients with multiple sclerosis where eosinophilia is induced by IL-5, produced by the immune response to parasites. 29163523 2017
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 Biomarker disease BEFREE Eosinophilic bronchitis is usually a Type 2 (T2)-driven process and therefore a sputum eosinophilia of greater than 3% usually indicates a response to treatment with corticosteroids or novel therapies directed against T2 cytokines such as IL-4, IL-5, and IL-13. 29018800 2017
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.600 AlteredExpression disease BEFREE IL-5 neutralization before allergen challenge abolished the allergen-induced rise in circulating eosinophils and expression of IL-3 receptors, whereas airway eosinophilia and eosinophil peroxidase deposition were blunted but not eliminated. 28862877 2017