Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE The transcript of FIP1L1-PDGFRA fusion gene is a genetic biomarker of clonal eosinophilia screened routinely by reverse transcript PCR (RT-PCR) during diagnosis. 30359545 2019
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE That ponatinib briefly induced remission in our patient with acute myeloid leukemia arising from a myeloproliferative neoplasm with eosinophilia and FIP1L1-PDGFRα fusion may merit exploration of ponatinib as a potential second-line treatment option for this patient population. 30184522 2018
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE Myeloid neoplasm with eosinophilia associated with isolated extramedullary FIP1L1/PDGFRA rearrangement. 29310833 2018
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE We describe identification of a FIP1L1-PDGFRA fusion in a 13-year-old boy who presented with T-lymphoblastic leukemia/lymphoma without eosinophilia. 29025601 2017
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE The FIP1L1-PDGFRA (FP) fusion gene is identified in a substantial proportion of patients with eosinophilia-associated myeloproliferative neoplasms (MPN-eo) who subsequently achieve rapid and durable remissions on imatinib. 26797429 2016
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE We report a 29-year-old man with double hip pain and lower limb weakness for 6 months with myeloid neoplasm with FIP1L1-PDGFRA rearrangement without marked peripheral blood eosinophilia. 26666578 2016
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE Interestingly, elevated expression of Hes1 was found in two of five samples of Fip1-like1 platelet-derived growth factor receptor-α (FIP1L1-PDGFA)-positive myeloid neoplasms associated with eosinophilia. 24486648 2014
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE The presence of a dominant neoplastic clone with FIP1L1-PDGFRA rearrangement was suspected on the basis of sudden onset of peripheral and bone marrow eosinophilia and confirmed by fluorescence in situ hybridization and molecular diagnostic tests. 24669761 2014
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE The fusion product of such genes is a tyrosine kinase oncoprotein sensitive to imatinib, which to date results to be the standard of care for FIP1L1-PDGFRA-positive chronic myeloproliferative disorders with eosinophilia. 24460680 2014
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE In certain eosinophilic diseases, activation of tyrosine kinase after fusion of the Fip1-like-1 and platelet-derived growth factor receptor-α genes (F-P fusion gene) mediates eosinophilia via downstream effectors such as extracellular-regulated kinase (ERK1/2) and signal transducers and activators of transcription (STAT5). 21819482 2012
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE However, after treatment with hydroxyurea and serial phlebotomies had been started, the patient developed hypereosinophilia, fitting the category of a myeloproliferative neoplasm with eosinophilia associated with the FIP1L1-PDGFRA gene fusion, as confirmed by molecular analysis. 22944561 2012
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE Patients with FIP1L1-PDGFRA fusion presented with more bone marrow eosinophils and peripheral blood eosinophilia as well as anemia, leukocytosis and thrombocytopenia. 22806436 2012
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE The FIP1L1-PDGFRA fusion gene is the most frequent genetic aberration in myeloid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1. 20589620 2010
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE The FIP1L1-PDGFRA fusion gene is a recurrent molecular abnormality in patients with eosinophilia-associated myeloproliferative neoplasms. 18987651 2009
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE The presence of eosinophilia, although prevalent (34%), was prognostically neutral, and the overall results were not affected by exclusion of FIP1L1-PDGFRA-positive cases. 19713463 2009
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias. 18843283 2008
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE We genotyped six single-nucleotide polymorphisms (SNP) within or close to the IL5RA or IL5 genes in 82 patients with FIP1L1-PDGFRA-positive CEL plus, as controls, healthy individuals (n=100), patients with FIP1L1-PDGFRA-negative eosinophilia (n=100) or patients with chronic myeloid leukaemia (CML) (n=100). 17914408 2007
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma. 17377585 2007
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE The FIP1L1-PDGFRA fusion gene is a recurrent molecular lesion in eosinophilia-associated myeloproliferative disorders, predicting a favorable response to imatinib mesylate. 17299092 2007
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. 17628645 2007
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 Biomarker disease BEFREE We now extend our observations through a study of 741 unselected patients with eosinophilia for FIP1L1-PDGFRA, and present longer term follow up data for the imatinib-treated cohort. 16406016 2006
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE On the basis of these findings, we screened for the expression of the FIP1L1-PDGFRalpha fusion gene and for mutations in the juxtamembrane and tyrosine kinase domains of PDGFRalpha/beta genes in 22 cases of CBF leukemia with eosinophilia. 16343267 2006
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE Discovery of the cryptic FIP1L1-PDGFRA gene fusion in cytogenetically normal patients with systemic mast cell disease with eosinophilia or idiopathic HES has redefined these diseases as clonal eosinophilias. 15995322 2005
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease BEFREE FIP1L1-PDGFRA is a relatively infrequent but treatment-relevant mutation in primary eosinophilia that is indicative of an underlying systemic mastocytosis. 15284118 2004
Entrez Id: 81608
Gene Symbol: FIP1L1
FIP1L1
0.100 GeneticVariation disease LHGDN FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. 15284118 2004