| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Further functional analysis showed that miR-542-3p overexpression inhibited KA-induced average seizure frequency, damage of hippocampal neuron and cell apoptosis, leading to alleviation of the brain injury in epilepsy rats. miR-542-3p was determined to downregulate TLR4 expression. | 31702493 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | MiR-181b could inhibit P38/JNK signaling pathway via targeting TLR4, thereby exerting protective roles in attenuating autophagy and apoptosis of KA-induced epileptic juvenile rats. | 29808547 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In conclusion, both HMGB1 and TLR4 expressions were correlated with increased risk and severity of epilepsy and their level was higher in patients resistant to anti-epilepsy drugs. | 31241711 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | The current study investigates the role of toll-like receptor 4 (TLR4) and its underlying mechanisms in kainic acid- (KA-) induced epileptic seizures in rats. | 29682548 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Correlation between level of TLR4 expression and disease duration or frequency of epileptic seizures in patients was also analyzed. | 29382328 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | HMGB1 mediates microglia activation via the TLR4/NF-κB pathway in coriaria lactone induced epilepsy. | 29393419 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | We conclude that IL-1R1/TLR4 is a novel potential therapeutic target for attaining disease-modifications in patients with diagnosed epilepsy. | 27939857 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | A total of 140 patients with NCC (82 symptomatic [ie, with active epilepsy] and 58 asymptomatic) and 150 healthy control subjects were examined for TLR4 Asp299Gly and Thr399Ile polymorphisms by means of polymerase chain reaction and restriction fragment-length polymorphism. | 20807077 | 2010 |