Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8493
Gene Symbol: PPM1D
PPM1D
0.010 AlteredExpression group BEFREE Here, UALCAN, an interactive web-portal to perform the expression analyses of PPM1D using TCGA gene expression data, and PPM1D high expression was exhibited in primary esophageal cancer. 30374621 2020
Entrez Id: 81628
Gene Symbol: TSC22D4
TSC22D4
0.010 Biomarker group BEFREE CRISPR/Cas9 gene editing was used to establish THG-1 knockout (KO) cells in a THG-1 positive esophageal tumor cell line. 31806366 2020
Entrez Id: 11061
Gene Symbol: CNMD
CNMD
0.010 AlteredExpression group BEFREE Using 41 samples of superficial esophageal cancer (EP and LPM 19 cases, MM or deeper 22 cases) and 7 samples of regenerative squamous epithelium, the expression of VEGF-A and ChM-1 was examined in relation to the histological grade or morphology of the surface microvasculature demonstrated by magnifying endoscopy (types A, B, and C correspond to types A, B1, and B2 and B3 of the magnifying endoscopic classification of the Japan Esophageal Society, respectively). 31595395 2020
Entrez Id: 84528
Gene Symbol: RHOXF2
RHOXF2
0.010 Biomarker group BEFREE CRISPR/Cas9 gene editing was used to establish THG-1 knockout (KO) cells in a THG-1 positive esophageal tumor cell line. 31806366 2020
Entrez Id: 8451
Gene Symbol: CUL4A
CUL4A
0.010 Biomarker group BEFREE Although the altered expression of CUL4A has been reported in several human cancers, the role of CUL4A in esophageal cancer remains unknown. 31535245 2020
Entrez Id: 1001
Gene Symbol: CDH3
CDH3
0.010 AlteredExpression group BEFREE Firstly, mRNA levels of ADAMTS9-AS2 and CDH3 in esophageal cancer tissues and cells were detected by reverse-transcription quantitative polymerase chain reaction. 31621118 2020
Entrez Id: 51363
Gene Symbol: CHST15
CHST15
0.010 Biomarker group BEFREE CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer. 31746400 2020
Entrez Id: 574460
Gene Symbol: MIR498
MIR498
0.010 AlteredExpression group BEFREE <b>Results</b>: There were overly expressed UCA1 and ZEB2 and lowly expressed miR-498 in EC tissues and cells. 31387451 2019
Entrez Id: 5934
Gene Symbol: RBL2
RBL2
0.010 Biomarker group BEFREE Intriguingly, E7 preferentially targeted p130 in the two esophageal cancer cell lines, instead of pRb as in cervical cancer. 31830929 2019
Entrez Id: 10103
Gene Symbol: TSPAN1
TSPAN1
0.010 AlteredExpression group BEFREE Tetraspanin 1 (TSPAN1), a novel member of the TSPAN superfamily, is highly expressed in many types of cancer, including gastric, colon, liver and esophageal cancer. 30720116 2019
Entrez Id: 7874
Gene Symbol: USP7
USP7
0.010 AlteredExpression group BEFREE Pharmaceutical or genetic inactivation of USP7 inhibited esophageal cancer cells growth in vitro and in vivo and induced apoptosis. 30182448 2019
Entrez Id: 378805
Gene Symbol: LINC-PINT
LINC-PINT
0.010 Biomarker group BEFREE In conclusion, linc-PINT-miR-543/miR-576-5p pathway could predict the prognosis and provide novel therapeutic targets for esophageal cancer. 31464068 2019
Entrez Id: 3239
Gene Symbol: HOXD13
HOXD13
0.010 AlteredExpression group BEFREE Moreover, the increase in sCD226 during chemotherapy was associated with poor treatment response (P = 0.019). sPD-1 levels are possibly dependent on the tumor aggressiveness of the esophageal cancer. 31134385 2019
Entrez Id: 6472
Gene Symbol: SHMT2
SHMT2
0.010 Biomarker group BEFREE However, the role of SHMT2 in gastric cancer (GC), esophageal cancer (ESCC), and colorectal cancer (CC) has not been clarified. 31773687 2019
Entrez Id: 7369
Gene Symbol: UMOD
UMOD
0.010 AlteredExpression group BEFREE A similar mutational pattern was observed in the mutational signature of esophageal cancer patients that demonstrated weak correlation with THP-dG levels. 31286759 2019
Entrez Id: 100628315
Gene Symbol: DNM3OS
DNM3OS
0.010 AlteredExpression group BEFREE Among the 38 lncRNAs tested, DNM3OS was found to have a much higher expression level in esophageal cancer cells than in Het-1A. 30463848 2019
Entrez Id: 574452
Gene Symbol: MIR494
MIR494
0.010 AlteredExpression group BEFREE Moreover, miR-494 was down-regulated in esophageal cancer tissues and cells. 30551480 2019
Entrez Id: 619555
Gene Symbol: MIR487A
MIR487A
0.010 AlteredExpression group BEFREE Subsequently, microRNA-487a expression in EC cell lines was detected as well. 30840272 2019
Entrez Id: 22930
Gene Symbol: RAB3GAP1
RAB3GAP1
0.010 Biomarker group BEFREE Intriguingly, E7 preferentially targeted p130 in the two esophageal cancer cell lines, instead of pRb as in cervical cancer. 31830929 2019
Entrez Id: 4010
Gene Symbol: LMX1B
LMX1B
0.010 Biomarker group BEFREE All these results indicated that LMX1B is a key regulator involved in the radioresistance of EC, which might be used as a biomarker to guide the clinical therapy of EC. 31545286 2019
Entrez Id: 9052
Gene Symbol: GPRC5A
GPRC5A
0.010 AlteredExpression group BEFREE High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients. 30707896 2019
Entrez Id: 54708
Gene Symbol: MARCHF5
MARCHF5
0.010 GeneticVariation group BEFREE However, the results remain inconclusive.We conducted a comprehensive meta-analysis including 63 articles with 66 studies containing 25,682 cases and 47,455 controls retrieved by searching PubMed and Embase electronic databases up to March 5, 2018.Pooled results indicated that ALDH2 gene rs671 polymorphism was significantly associated with the overall cancer risk in Asians (homozygous model: odds ratio [OR] = 0.85, 95% confidence interval [CI] = 0.72-0.99, P = .042; heterozygous model: OR = 1.32, 95% CI = 1.14-1.52, P  < .001; recessive model: OR = 0.73, 95% CI = 0.60-0.88, P = .001; dominant model: OR = 1.32, 95% CI = 1.16-1.51, P < .001; and allele comparison model: OR = 1.11, 95% CI = 1.03-1.19, P = .004), especially in esophageal cancer and among the Chinese and the Japanese.Our results suggest that ALDH2 rs671 polymorphism is associated with the overall cancer risk in Asians. 30921184 2019
Entrez Id: 8839
Gene Symbol: CCN5
CCN5
0.010 AlteredExpression group BEFREE WISP2 exhibits its potential antitumor activity via targeting ERK and E-cadherin pathways in esophageal cancer cells. 30808397 2019
Entrez Id: 6359
Gene Symbol: CCL15
CCL15
0.010 Biomarker group BEFREE In separate models, sEGFR and TSLP were nominally associated with gastric cancer risk, and CRP, CXCL11/ITAC, and CCL15/MIP1D were associated with esophageal cancer. 30877129 2019
Entrez Id: 3170
Gene Symbol: FOXA2
FOXA2
0.010 Biomarker group BEFREE Members of the forkhead-box A (FOXA) family, including FOXA1 and FOXA2, have been reported to regulate EC progression. 30944629 2019