Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5002
Gene Symbol: SLC22A18
SLC22A18
0.010 Biomarker group BEFREE 15-LOX-2 was expressed in normal esophageal epithelial cells (EECs) at the highest levels, whereas an SV40-immortalized HET-1A line and three of five esophageal cancer cell lines failed to express it at detectable levels. 12659684 2003
Entrez Id: 6294
Gene Symbol: SAFB
SAFB
0.010 Biomarker group BEFREE 15-LOX-2 was expressed in normal esophageal epithelial cells (EECs) at the highest levels, whereas an SV40-immortalized HET-1A line and three of five esophageal cancer cell lines failed to express it at detectable levels. 12659684 2003
Entrez Id: 692236
Gene Symbol: SNORD116@
SNORD116@
0.020 Biomarker group BEFREE 18F-FAMT PET Is Useful to Distinguish between Specific Uptake and Nonspecific Uptake Compared to 18F-Flourodeoxyglucose Position Emission Tomography in Esophageal Cancer Patients. 29130979 2018
Entrez Id: 54738
Gene Symbol: FEV
FEV
0.020 Biomarker group BEFREE 18F-FAMT PET Is Useful to Distinguish between Specific Uptake and Nonspecific Uptake Compared to 18F-Flourodeoxyglucose Position Emission Tomography in Esophageal Cancer Patients. 29130979 2018
Entrez Id: 5170
Gene Symbol: PDPK1
PDPK1
0.040 Biomarker group BEFREE 3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been reported to be closely correlated with proliferation, apoptosis and invasion of esophageal cancer cells. 25416048 2014
Entrez Id: 22915
Gene Symbol: MMRN1
MMRN1
0.010 Biomarker group BEFREE 3D cell-derived-ECMs and esophageal cancer cell lines were used as a model to investigate the effect of ECM proteins on esophageal cancer cell lines response to chemotherapeutics. 30241395 2018
Entrez Id: 1718
Gene Symbol: DHCR24
DHCR24
0.010 Biomarker group BEFREE 42 patients with squamous EC were prepared for DCE-MRI and DWI scans both before treatment (NRT) and after the fifth radiotherapy (5th RT). 31064001 2019
Entrez Id: 355
Gene Symbol: FAS
FAS
0.040 GeneticVariation group BEFREE 42:479-484) that functional polymorphisms in FAS and FAS ligand (FASL) are associated with susceptibility to lung cancer and esophageal cancer; however, the mechanisms underlying this association have not been elucidated. 16186185 2005
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
0.080 GeneticVariation group BEFREE Esophageal cancer in Chinese population: no polymorphism in codon 149 of P21(Waf1/Cip1) cyclin dependent kinase gene. 12400017 2002
Entrez Id: 56996
Gene Symbol: SLC12A9
SLC12A9
0.050 GeneticVariation group BEFREE Esophageal cancer in Chinese population: no polymorphism in codon 149 of P21(Waf1/Cip1) cyclin dependent kinase gene. 12400017 2002
Entrez Id: 367
Gene Symbol: AR
AR
0.030 GeneticVariation group BEFREE Esophageal cancer risk in relation to GGC and CAG trinucleotide repeat lengths in the androgen receptor gene. 12925954 2003
Entrez Id: 367
Gene Symbol: AR
AR
0.030 GeneticVariation group LHGDN Esophageal cancer risk in relation to GGC and CAG trinucleotide repeat lengths in the androgen receptor gene. 12925954 2003
Entrez Id: 339967
Gene Symbol: TMPRSS11A
TMPRSS11A
0.050 Biomarker group BEFREE Esophageal-cancer-related gene1 (ECRG1) short tandem repeats are associated with higher risk for developing esophageal squamous cell carcinoma. 19052822 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.090 Biomarker group BEFREE Esophageal cancer, which frequently exhibits coordinated loss of E-cadherin (Ecad) and transforming growth factor beta (TGFbeta) receptor II (TbetaRII), has a high mortality rate. 20563251 2010
Entrez Id: 84651
Gene Symbol: SPINK7
SPINK7
0.100 Biomarker group BEFREE Esophageal cancer-related gene 2 (ECRG2) is found to be critical in the process of carcinogenesis. 23079671 2012
Entrez Id: 339967
Gene Symbol: TMPRSS11A
TMPRSS11A
0.050 Biomarker group BEFREE Esophageal cancer-related gene 1 (ECRG1) is a novel tumor suppressor gene known to affect matrix remodeling, cell growth, and differentiation. 23869757 2013
Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7
0.010 GeneticVariation group BEFREE Esophageal cancer in a family with hamartomatous tumors and germline PTEN frameshift and SMAD7 missense mutations. 25554686 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker group BEFREE Esophageal cancer (ESC) is one of the most deadly diseases for human. p53 in most cancers, including ESC cell, is mutated, and the mutated p53 losses its original function and acquires "gain of function" that allows for promoting the hallmarks of cancer, such as antiapoptosis, metastasis, invasion, angiogenesis, and resistance to chemotherapy. 31354907 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.800 Biomarker group BEFREE Esophageal cancer is one primary human tumor in which MTS1 constitutes an apparent target of heterozygous or homozygous deletions occurring at chromosome 9p21. 7970734 1994
Entrez Id: 6275
Gene Symbol: S100A4
S100A4
0.040 Biomarker group BEFREE Esophageal cancer is one primary human tumor in which MTS1 constitutes an apparent target of heterozygous or homozygous deletions occurring at chromosome 9p21. 7970734 1994
Entrez Id: 6298
Gene Symbol: SAI1
SAI1
0.010 Biomarker group BEFREE Esophageal cancer is one primary human tumor in which MTS1 constitutes an apparent target of heterozygous or homozygous deletions occurring at chromosome 9p21. 7970734 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation group BEFREE Esophageal cancer has its unique pattern of P53 mutations in Hong Kong. 9594248 1997
Entrez Id: 2125
Gene Symbol: EVPL
EVPL
0.010 Biomarker group BEFREE Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25. 10409435 1999
Entrez Id: 3068
Gene Symbol: HDGF
HDGF
0.010 Biomarker group BEFREE Hepatoma-derived growth factor is associated with reduced sensitivity to irradiation in esophageal cancer. 11479204 2001
Entrez Id: 85409
Gene Symbol: NKD2
NKD2
0.020 AlteredExpression group BEFREE NKD2 was up-regulated in gastric cancer cell line MKN45, pancreatic cancer cell line BxPC-3, and esophageal cancer cell lines TE6, and TE13. 11604995 2001