Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Furthermore, Arg/Arg genotype of ADH1B Arg47His variant combined with drinking, smoking and males appeared to show a high risk in patients with esophageal cancer. 27450204 2016
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Associations between ADH1B genotypes and the risk of esophageal cancer were estimated by computing the odds ratios (ORs) and their 95% confidence intervals (CIs) using logistic regression analyses for crude ORs and adjusted ORs when adjusting for age, gender, and tobacco use status. 24093763 2014
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE This meta-analysis shows that the GG genotype of ADH2 G48A may be associated with an increased risk of EC in Asian populations. 24446180 2014
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE In addition, statistical interaction between ALDH2 and ADH1B polymorphisms on EC susceptibility among never/light drinkers was indicated. 22930414 2013
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group GWASCAT Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999 2012
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE The key findings of the earlier studies were that variations (i.e., polymorphisms) in the DNA sequences of the genes encoding alcohol dehydrogenase 1B (i.e., the ADH1B gene), aldehyde dehydrogenase 2 (i.e., the ALDH2 gene), and other alcohol-metabolizing enzymes mediate the risk for alcoholism; moreover, these polymorphisms also have an impact on the risk of alcohol-related cancers, such as esophageal cancer. 23134043 2012
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Genetic polymorphisms of the alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes are associated with the risk of esophageal cancer. 22703580 2012
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999 2012
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 Biomarker group BEFREE Women with inactive ADH1B and ALDH2 should reduce drinking and increase their intake of vegetable and fruit to prevent development of esophageal cancer. 22292652 2011
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 Biomarker group BEFREE Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus. 21601984 2011
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 Biomarker group BEFREE ADH1B*1/*1 increased the risk of esophageal cancer among never/rare [1.56 (0.93-2.61)], moderate [2.71 (1.37-5.35)], and heavy drinkers [3.22 (2.27-4.57)]. 20806441 2010
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Compared with individuals carrying both ALDH2 G/G and ADH2 A/A alleles and with a cumulative amount of alcohol consumption <2.5 (kg * years), drinkers carrying both ALDH2 A and ADH2 G alleles and with a cumulative amount of alcohol consumption > or =2.5 (kg * years) showed a significantly elevated risk of esophageal cancer (OR=53.15, 95% CI: 4.24-666.84). 20010786 2010
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China. 21157980 2010
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group GWASDB Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. 20833657 2010
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. 21048924 2010
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Both ADH2 G allele and ALDH2 A allele significantly increase the risk of esophageal cancer development in Southeast Chinese males. 19452585 2009
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group GWASCAT Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. 19698717 2009
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. 19698717 2009
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 Biomarker group CTD_human Multiple ADH genes are associated with upper aerodigestive cancers. 18500343 2008
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group LHGDN ADH2 and ALDH2 genotypes are associated with esophageal cancer risk. 17963305 2007
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE ADH2 and ALDH2 genotypes are associated with esophageal cancer risk. 17963305 2007
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE We also found a modifying effect of lifetime alcoholic consumption on the association between genotypes of ADH1B and ALDH2 on esophageal cancer risk. 17036331 2006
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group LHGDN We also found a modifying effect of lifetime alcoholic consumption on the association between genotypes of ADH1B and ALDH2 on esophageal cancer risk. 17036331 2006
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 Biomarker group BEFREE Significant gene-environment interactions between alcohol drinking and both ADH2 and ALDH2 were observed regarding esophageal cancer risk. 16235983 2005
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.500 GeneticVariation group BEFREE Our findings suggest that polymorphisms of ADH2 and ALDH2 can modify the influence of alcoholic consumption on esophageal cancer risk. 16127737 2005