| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | group | BEFREE | Genetic changes associated with the development of EC involve the p16, p53, and APC genes. | 29776635 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | Our results imply that APC methylation detection is a potential diagnostic biomarker for EC and BE. | 29440928 | 2018 | ||||
|
0.070 | AlteredExpression | group | BEFREE | Thirty-six of 59 patients (61.0%) with esophageal cancer had detectable levels of methylated DAPK or APC promoter DNA and preoperative detection was significantly associated with an unfavorable prognosis as revealed by multivariate Cox proportional hazards regression analysis [Exp(b) = 4.578; P = 0.01]. | 19259700 | 2009 | ||||
|
0.070 | PosttranslationalModification | group | BEFREE | In conclusion, promoter hypermethylation of the APC gene is related to a lower number of metastatic lymph nodes and to superior prognosis in terms of recurrence, which suggests it might be involved in the process of lymph node metastasis in esophageal cancer. | 18847451 | 2009 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Frequently reported genome alterations were: the +3q27 and +8q24 mutations of TP53 for esophageal cancer; +20q13 for gastric cancer; -18q22 and +20q12-q13 mutations of APC, TP53 and KRAS for colorectal cancer, and the -18q22 mutation of KRAS and TP53 for pancreatic cancer. | 19023234 | 2008 | ||||
|
0.070 | GeneticVariation | group | BEFREE | The low rate of APC mutation observed here, coupled with the high reported rate of loss of heterozygosity on chromosome 5q, suggests the possibility that a gene or genes on chromosome 5q distinct from APC may be the target(s) of allelic deletion in most esophageal tumors. | 7958689 | 1994 | ||||
|
0.070 | GeneticVariation | group | BEFREE | We examined 72 esophageal tumors (46 squamous cell carcinomas and 26 adenocarcinomas) for loss of heterozygosity at the p53, Rb, APC, MCC, and DCC loci. | 1423299 | 1992 |