Gene: PTGS2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group BEFREE Methylation‑associated silencing of miR‑128 promotes the development of esophageal cancer by targeting COX‑2 in areas with a high incidence of esophageal cancer. 30535495 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE Evaluating the expression of cyclooxygenase-2 enzyme by immunohistochemistry in normal and tumoral tissue before and after neoadjuvant chemoradiotherapy in patients with esophageal cancer in Khorasan Province. 29893307 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE Thus, this meta-analysis was conducted to comprehensively evaluate the impact of COX-2 expression on the prognostic value in patients with EC. 28652771 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group BEFREE In the present study, we demonstrated that celecoxib antagonized oxaliplatin-induced cytotoxicity and apoptosis independent of COX-2 inhibition in human esophageal cancer cells. 26474693 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 GeneticVariation group BEFREE We performed a gene-wide tag SNP-based association study to examine the association of SNPs in PTGS2 and PLA2G2A with ESCC in 269 patients and 269 healthy controls from Taihangshan Mountain, Henan and Hebei Provinces, the rural area of China which has the highest incidence of esophageal cancer in the world. 24641411 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE Furthermore, treatment of siRNA for APE-1 significantly reduced COX-2 expression and VEGF production in MCP-1-stimulated esophageal cancer cell lines. 24284961 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group BEFREE Promising markers that emerged for the prediction of overall survival in esophageal squamous cell cancer included VEGF (18 eligible studies, n=1476, HR=1.85, 95% CI, 1.55-2.21), cyclin D1 (12 eligible studies, n=1476, HR=1.82, 95% CI, 1.50-2.20), Ki-67 (3 eligible studies, n=308, HR=1.11, 95% CI, 0.70-1.78) and squamous cell carcinoma antigen (5 eligible studies, n=700, HR=1.28, 95% CI, 0.97-1.69); prognostic markers for esophageal adenocarcinoma included COX-2 (2 eligible studies, n=235, HR=3.06, 95% CI, 2.01-4.65) and HER-2 (3 eligible studies, n=291, HR=2.15, 95% CI, 1.39-3.33); prognostic markers for uncategorized ECs included p21 (9 eligible studies, n=858, HR=1.27, 95% CI, 0.75-2.16), p53 (31 eligible studies, n=2851, HR=1.34, 95% CI, 1.21-1.48), CRP (8 eligible studies, n=1382, HR=2.65, 95% CI, 1.64-4.27) and hemoglobin (5 eligible studies, n=544, HR=0.91, 95% CI, 0.83-1.00). 24206575 2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group RGD Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma. 22165968 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 GeneticVariation group BEFREE A large number of studies have demonstrated a strong association between COX-2 polymorphisms and EC risk. 21304218 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE The esophageal cancer cell lines (EC9706) that express COX-2 permanently and hepatocellular carcinoma cell lines (SMMC7721) while no expression of COX-2 were studied. 18443952 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE Esophageal tissue with a positive expression of p53 or COX-2 was more likely to develop esophageal cancer. 17650224 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. 17511025 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group CTD_human Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms. 17707579 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group CTD_human We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer. 16322294 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE The association of several clinicopathological parameters with the immunohistochemical expression of COX-2 was analyzed in paraffin-embedded esophageal cancer specimens. 15978332 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 GeneticVariation group BEFREE These findings indicate that genetic variants in COX-2 may play a role in mediating susceptibility to esophageal cancer. 16083713 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer. 16322294 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE Up-regulation of COX-2 mRNA and protein was observed in esophageal cancer cells transfected with heparanase cDNA. 16299228 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 GeneticVariation group LHGDN These findings indicate that genetic variants in COX-2 may play a role in mediating susceptibility to esophageal cancer. 16083713 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group BEFREE Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. 15151617 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group BEFREE These results suggest that COX-2 may be an important factor for esophageal cancer and inhibition of COX-2 may be helpful for prevention and possibly treatment of this cancer. 15259059 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group LHGDN These results suggest that COX-2 may be an important factor for esophageal cancer and inhibition of COX-2 may be helpful for prevention and possibly treatment of this cancer. 15259059 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 AlteredExpression group BEFREE Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. 11821953 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group BEFREE NS398 decreased cell viability in 2 cyclo-oxygenase-2-positive (COX-2(+)) esophageal cancer cell lines but not in a COX-2(-) cell line. 11410869 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.600 Biomarker group CTD_human Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. 11059772 2000