Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy.
In addition, esophageal stenosis (HR=4.089, 95% CI 1.451-11.527, <i>p</i>=0.008), T stage (HR=2.663, 95% CI 1.019-6.960, <i>p</i>=0.046), and CEA (HR=0.309, 95% CI 0.124-0.768, <i>p</i>=0.011) were revealed as risk parameters in further multivariate analysis.
Herein, we describe the first case of a patient who developed autoimmune mucositis and esophagitis complicated by a severe refractory esophageal stenosis induced during treatment by nivolumab, which completely resolved after personalized treatment with tocilizumab, suggesting a role of IL-6 blockade in the management of severe steroid refractory esophageal stenosis and more broadly in refractory immune-related adverse events.
A novel germline KIT mutation (p.L576P) in a family presenting with juvenile onset of multiple gastrointestinal stromal tumors, skin hyperpigmentations, and esophageal stenosis.