Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Previously, we demonstrated that Fsp27a is directly regulated by peroxisome proliferator-activated receptor γ (PPARγ) in fatty livers of genetically obese leptin deficient ob/ob mice and that Fsp27b may potentially be regulated by different factors transcriptionally as they both have a different promoter region. 31564684 2020
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Laboratory examinations and abdominal ultrasonography revealed diabetes mellitus, insulin-resistance, dyslipidemia, decreased serum leptin levels (2.2 ng/mL), elevated serum hepatobiliary enzyme levels and fatty liver. 31708526 2020
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE MF treatment led to a decrease in food intake, the body and fat weights, the plasma levels of glucose, insulin and leptin, all increased in agouti-mice, to an improvement of the lipid profile and glucose sensitivity, and to a reduced fatty liver degeneration. 30870482 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver. 31167890 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE These results demonstrate that RSV restored leptin sensitivity in a cellular model of hepatic steatosis in a SIRT1-independent manner. 31842467 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 GeneticVariation disease BEFREE Fatty liver in lipodystrophy: A review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement. 31071311 2019
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Circulating WISP-1/CCN4 positively correlated with body mass index, body fat percentage, leptin and triglyceride levels, hip circumference and fatty liver index. 29129025 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Aging is a significant risk factor for the development of obesity and hepatic steatosis associated with insulin and leptin resistance. 29575696 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE High-fat diet (60% kcal) was used to induce fatty liver phenotype with parallel insulin and leptin resistance. 29660503 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Alcohol exposure around conception increases obesity risk, alters plasma lipid and leptin profiles, and induces liver steatosis in a sex-specific manner. 29089335 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Here we show that high intake of salt activates the aldose reductase-fructokinase pathway in the liver and hypothalamus, leading to endogenous fructose production with the development of leptin resistance and hyperphagia that cause obesity, insulin resistance, and fatty liver. 29507217 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 PosttranslationalModification disease BEFREE Melatonin reverses leptin methylation and expression and decreases inflammation and chronic liver steatosis not via apoptosis or histone deacetylation (HDAC). 30424542 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE In the multiple regression analysis leptin, sObR, FLpI, waist-to-hip ratio, HbA1c, lipids, and HOMA-IR correlated independently with HS (P < 0.0001 for all). 30052309 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Our results suggest that mSJH exerts an anti-hepatic steatosis effect via activation of leptin and associated signaling cascades related to lipid metabolism. 28358008 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease MGD Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. 25621497 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE We investigated the liver effect of leptin independently of insulin sensitization and appetite suppression using hepatocyte-specific Pten-deficient (AlbCrePtenff) mouse, a model of severe fatty liver with insulin hypersensitivity. 25415231 2015
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice. 24525044 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791 2014
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptin-deficient girl. 23651953 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease BEFREE Leptin improved the fatty liver possibly by activating hepatic AMPK through the central and sympathetic nervous systems. 23024365 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE Adoptive transfer of iNKT cells into obese mice or in vivo activation of iNKT cells via their lipid ligand, alpha-galactocylceramide, decreased body fat, triglyceride levels, leptin, and fatty liver and improved insulin sensitivity through anti-inflammatory cytokine production by adipose-derived iNKT cells. 22981538 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 AlteredExpression disease BEFREE In logistic regression analysis, only insulin resistance was associated with portal inflammation), lobular inflammation and steatosis; liver steatosis was related with leptin levels, too. 22530350 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.600 Biomarker disease MGD Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet. 22118645 2011