Saxagliptin can effectively improve blood glucose, blood lipid and liver function and reduce the protein expression of HIF-1α in diabetic rats with fatty liver.
When exposed to a choline-deficient diet (CDD) for 4 weeks, the loss of hepatic Hif-1α gene accelerated liver steatosis with enhanced triglyceride accumulation in the liver compared to wild-type (WT) livers.