| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Interestingly, activation of AMPK by metformin causes an augmentation of Insig stability and reduction of lipogenic gene expression, and leads to the attenuation of hepatic steatosis in HFHS diet-fed mice. | 30733434 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our data provided new evidence supporting the preventive role of 500 mg/(kg·bw·day) APE treatment in the HFD-induced hepatic steatosis in C57BL/6 mice via the LKB1/AMPK pathway. | 31608624 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | These findings revealed that diminished AMPK/TFEB-dependent autophagy is involved in the pathogenesis of liver steatosis in obesity, and that CAT might be a novel therapeutic candidate for treatment of this condition. | 31697646 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our results demonstrate that AS-IV attenuates FFA-induced ER stress and lipid accumulation in an AMPK-dependent manner in hepatocytes, which supports its use as promising therapeutics for hepatic steatosis. | 28344322 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Pectic Bee Pollen Polysaccharide from Rosa rugosa Alleviates Diet-Induced Hepatic Steatosis and Insulin Resistance via Induction of AMPK/mTOR-Mediated Autophagy. | 28452943 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. | 29092796 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Taken together, these results indicate that MIF is highly expressed in the liver during physical exercise and may prevent hepatic steatosis by activating the AMPK pathway. | 23823021 | 2013 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. | 21459323 | 2011 |