We also combined LPS (100μg/kg) treatment with intracerebroventricular (icv) injection of 5-HT (5, 10 and 40μg/μL) and measured Tb ("hallmark" of SI), AVPO prostaglandin E<sub>2</sub> [(PGE<sub>2</sub>) - an essential mediator of fever] and prostaglandin D<sub>2</sub> [(PGD<sub>2</sub>) - a cryogenic mediator], plasma corticosterone [(CORT) - a stress marker with an endogenous anti-inflammatory effect] and interleukin-6 [(IL-6) - an immune mediator] levels.