Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Therapeutic phenotype CTD_human Hyponatremia and other toxic effects during a phase I trial of recombinant human gamma interferon and vinblastine. 3091246 1986
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker phenotype CTD_human Hyponatremia and other toxic effects during a phase I trial of recombinant human gamma interferon and vinblastine. 3091246 1986
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker phenotype BEFREE Low grade fever and malaise were common with the first injection of interferon gamma, but no serious side effects were encountered. 15913831 2005
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker phenotype BEFREE While systemic delivery - the major route used to administer IFN-gamma - results in significant side effects and toxicity, including fever, fatigue, nausea, vomiting and neurotoxicity, transdermal delivery has a very low transduction efficiency. 15804234 2005
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker phenotype BEFREE Together, our findings propose that IFN-gamma could be a useful potentiator of hyperthermia and cisplatin in cancer therapy. 18497994 2008
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker phenotype CTD_human Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity. 18282668 2008
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Therapeutic phenotype CTD_human Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity. 18282668 2008
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression phenotype BEFREE Using an organotypic culture system, we found that hyperthermia at 42 °C and 45 °C could induce a significant increase in the transcriptional expression of interferon (IFN)-α, IFN-β and IFN-γ, in a temperature-dependent manner in condyloma acuminata (CA), but not in normal skin. 20797409 2010
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 GeneticVariation phenotype BEFREE The association of IFN-γ rs2069705 with the risk of breast cancer was not significant among all participants, while the CT/TT genotypes were significantly related to an elevated risk of breast cancer [1.32 (1.03-1.70)] among the women with <1 fever per year and to a reduced risk of breast cancer [0.63 (0.40-0.99)] among women with ≥1 fever per year compared to the CC genotype. 22624006 2012
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression phenotype BEFREE Our aim was to investigate the effects of hyperthermia, ultraviolet A rays (UVA), and ultraviolet C rays (UVC) as well as glucose and ascorbic acid (AA) on the regulation of human β-defensin 1 (DEFB1), cathelicidin (CAMP), and interferon-γ (IFNG) genes in normal human keratinocytes (NHK). 25815330 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression phenotype BEFREE Vaccination significantly reduced fever and interferon-gamma (IFNγ) levels in swine challenged with virulent S. Typhimurium compared to mock-vaccinated pigs. 28516860 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression phenotype BEFREE Hyperthermia increased expression of IL-10, TGF-β1 and FOXP3 mRNAs in co-culture; however, no effects on IL-17A and IFN-γ were observed, and it reduced CXCL12 expression. 28540823 2017
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression phenotype BEFREE BKI-1553 treatment decreased fever in infected pregnant ewes already after two applications, resulted in a 37-50% reduction in foetal mortality, and modulated immune responses; IFNγ levels were increased early after infection and IgG levels were reduced subsequently. 29501973 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 AlteredExpression phenotype BEFREE CD4+CD25+high levels showed significant correlation with serum C4, IFN-γ and IL-10 levels in healthy subjects and with C4 levels and fever in SLE patients. 30325682 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.400 Biomarker phenotype BEFREE As the temperature increase, there is a U shape for immune proteins and pro-inflammatory factors with a peak value at 24 °C, exception for IFN-γ (inverted U-shape). 31761597 2020