Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Systemic inflammation and the fever response to pathogens are coordinately regulated by IL-6 and IL-1β. 30674283 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Proinflammatory cytokines, tumor necrosis factor α, interleukin 1 (IL-1), IL-2, interferon γ (IFNγ), and macrophage chemoattractant protein 1 elicit fever, inflammation, multiple organ injury, hypotension, and lethal shock. 30909619 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE In this study, we examined the possible effects of anti-Ly6G-mediated systemic neutrophil depletion and liposome-encapsulated clodronate (LEC)-mediated systemic macrophage depletion on the inflammatory signs (thermal hyperalgesia, mechanical allodynia, oedema and fever) and measured the levels of various inflammation markers (tumour necrosis factor-α (TNF-α), interleukins (IL)-1β, IL-4, IL-10, macrophage inflammatory protein-1 alpha (MIP-1α/CCL3) and myeloperoxidase (MPO) in paw and spinal cord tissues in carrageenan (CG)-induced hindpaw inflammation model in rats. 30680651 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation phenotype BEFREE Our results indicate that certain haplotypes in the IL-1 gene complex and in IL18 and IL4 predict an altered likelihood of the development of fever after smallpox vaccination. 17570108 2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE It has been shown that interleukin-1β (IL-1β) is intrinsically involved in the febrile response in children and in the generation of FSs. 22622830 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE Buthionine sulfoximine, a glutathione depletor, attenuates endotoxic fever and reduces IL-1β and IL-6 level in rats. 27764704 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE The L83L ORF of African swine fever virus strain Georgia encodes for a non-essential gene that interacts with the host protein IL-1β. 29605728 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Treatment with the highest dose of EA-230 resulted in a significant attenuation of the LPS-induced increase in plasma levels of inflammatory mediators interleukin (IL)-6, IL-8, IL-1 receptor antagonist, monocyte chemoattractant protein-1, macrophage inflammatory proteins-1α and -1β, and vascular cell adhesion protein-1 (% reduction of 48, 28, 33, 28, 14, 16 and 19 respectively, p < .01), and reduced fever (peak decrease from 1.8 ± 0.1°C to 1.3 ± 0.2°C, P < .05) and symptom scores (peak decrease from 7.4 ± 1.0 to 4.0 ± 1.2 points, P < .05). 30919998 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype RGD In conclusion, our results show that ET-1 increases IL-1 production in the POA, and this effect appears to be correlated to ET-1-induced fever in vivo, as well as to PG production in vitro. 16455768 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1β is one of the most prominent mediators of inflammation resulting in fever and immune activation via binding to IL-1 receptor 1. 27734407 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE One case with repeated fever attacks after tonsillectomy showed increased monocyte IL-1β production, similar to the other active case with genetic variants of auto inflammatory disorder-associated genes. 24760114 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 mediates host defence responses to local and systemic disease and injury (e.g. fever, slow-wave sleep, appetite suppression and neuroendocrine responses) and to neuroinflammation and cell death in neurodegenerative conditions, such as stroke and head injury. 11137152 2000
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE CAPS are associated with gain-of-function mutations in the NLRP3 inflammasome, a multiprotein complex critical for the activation of IL-1ß, and are characterized by episodes of fever, urticaria-like rash, musculoskeletal, ocular, and neurological symptoms. 28586272 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human However, pretreatment with either the IL-1 receptor antagonist or the cyclooxygenase inhibitor flurbiprofen completely abolishes adenovirus-induced fever, suggesting that IL-1 and prostaglandins are direct mediators of this response. 9952427 1999
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-18 uniquely induces IFN-gamma from T lymphocytes and natural killer cells but does not cause fever, whereas fever is a prominent characteristic of IL-1 in humans and animals. 15161979 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Tumor necrosis factor shares with IL-1 many of the systemic and local effects of IL-1; these include fever, acute phase protein synthesis and sleep. 3127333 1987
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Because PGE<sub>2</sub> mediates the pyrogenic effect of IL-1β, these effects might be especially relevant for the role of monocytes in the induction of fever. 28298525 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. 24668705 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Differences between early presymptomatic infection and natural infection involved genes that regulate the induction of apoptosis through mitogen-activated protein (MAP) kinases and signaling pathways through the endogenous pyrogen IL-1beta, a major inducer of fever. 16988231 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE CAPS are associated with GOF mutations in the NLRP3 inflammasome and activation of IL-1ß leading to episodes of fever, cutaneous, musculoskeletal, articular, ocular, and neurological symptoms. 29610014 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE These results support the hypothesis that elevated temperature is one of the physiologic signals for down-regulation of IL-1 beta biosynthesis through a mechanism related to the induction of hsp. 3139749 1988
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 beta-induced fever can be blocked by IL-1ra pretreatment. 9629236 1998
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Interleukin 1 (IL-1) is a 17 kDa protein highly conserved through evolution and is a key mediator of inflammation, fever and the acute-phase response. 20173777 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1β, IL-6, and TNF-α) release, and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) synthesis (both peripherally and hypothalamic)]. 28667503 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Therefore, P2X7R antagonists emerge as novel therapeutics for the treatment for acute inflammation, pain and fever, with wider anti-inflammatory activity than currently used cyclooxygenase inhibitors.-Barberà-Cremades, M., Baroja-Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., Pelegrín, P. P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release. 22490780 2012