Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 mediates host defence responses to local and systemic disease and injury (e.g. fever, slow-wave sleep, appetite suppression and neuroendocrine responses) and to neuroinflammation and cell death in neurodegenerative conditions, such as stroke and head injury. 11137152 2000
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 are important for the synthesis of acute phase proteins, and it is a pyrogen cytokine that may cause fever. 20080142 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1β is a major mediator of fever and systemic inflammation, and mononuclear cells from FMF patients release higher levels of IL-1β. 22406096 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses. 24668705 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1β is an important mediator of inflammation and fever is also important information of FCs. 26813462 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1β is one of the most prominent mediators of inflammation resulting in fever and immune activation via binding to IL-1 receptor 1. 27734407 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1β was not detected in any samples, while HSP70 was detectable immediately after exposure to a temperature increase of 6 °C or more. 30176259 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-1 beta-induced fever can be blocked by IL-1ra pretreatment. 9629236 1998
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human A comparative study of the antipyretic effects of indomethacin and dipyrone in rats. 11852909 2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Additional studies showed that CSFV-induced IL-1β secretion was mediated by NLRP3 and that CSFV infection could sufficiently activate the assembly of the NLRP3 inflammasome in monocytes. 30013955 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Administration of IL-1ß induced fever, lethargy and anorexia for∼two-to-three days and increased the concentration of IL-1ß in the hippocampus and hypothalamus for at least eight hours. 28212946 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Because PGE<sub>2</sub> mediates the pyrogenic effect of IL-1β, these effects might be especially relevant for the role of monocytes in the induction of fever. 28298525 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE Buthionine sulfoximine, a glutathione depletor, attenuates endotoxic fever and reduces IL-1β and IL-6 level in rats. 27764704 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE CAPS are associated with gain-of-function mutations in the NLRP3 inflammasome, a multiprotein complex critical for the activation of IL-1ß, and are characterized by episodes of fever, urticaria-like rash, musculoskeletal, ocular, and neurological symptoms. 28586272 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE CAPS are associated with GOF mutations in the NLRP3 inflammasome and activation of IL-1ß leading to episodes of fever, cutaneous, musculoskeletal, articular, ocular, and neurological symptoms. 29610014 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1β, IL-6, and TNF-α) release, and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) synthesis (both peripherally and hypothalamic)]. 28667503 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation phenotype BEFREE Cyclic paroxysm and high fever are hallmarks of malaria and are associated with high levels of pyrogenic cytokines, including IL-1β. 24453977 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever. 25164664 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE Differences between early presymptomatic infection and natural infection involved genes that regulate the induction of apoptosis through mitogen-activated protein (MAP) kinases and signaling pathways through the endogenous pyrogen IL-1beta, a major inducer of fever. 16988231 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE ETAF/IL-1 has a multiplicity of divergent biological effects: enhancement of thymocyte proliferation, stimulation of cells in the hypothalamus to mediate fever, leukocyte chemotaxis, stimulation of hepatic synthesis of acute-phase proteins, augmentation of IL-2 production and keratinocyte proliferation. 2854717 1988
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression phenotype BEFREE Freshly isolated leukemic cells from patients with adult T-cell leukemia (ATL) produce high levels of interleukin-1 (IL-1), which is believed to play an important role in neutrophilia, elevation of C-reactive protein, osteolytic bone lesions, hypercalcemia, and fever in ATL. 7628587 1995
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype CTD_human However, pretreatment with either the IL-1 receptor antagonist or the cyclooxygenase inhibitor flurbiprofen completely abolishes adenovirus-induced fever, suggesting that IL-1 and prostaglandins are direct mediators of this response. 9952427 1999
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE IL-18 uniquely induces IFN-gamma from T lymphocytes and natural killer cells but does not cause fever, whereas fever is a prominent characteristic of IL-1 in humans and animals. 15161979 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype RGD In conclusion, our results show that ET-1 increases IL-1 production in the POA, and this effect appears to be correlated to ET-1-induced fever in vivo, as well as to PG production in vitro. 16455768 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker phenotype BEFREE In this report, the effects of elevated temperature and dexamethasone on LPS-stimulated IL-1 beta and TNF alpha mRNA gene expression and protein synthesis were studied in human astrocytoma cell lines and primary cultures of human fetal astrocytes. 2022738 1991